DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17739 and CG30203

DIOPT Version :9

Sequence 1:	NP_610757.1	Gene:	CG17739 / 36333	FlyBaseID:	FBgn0033710	Length:	873	Species:	Drosophila melanogaster
Sequence 2:	NP_725128.2	Gene:	CG30203 / 246514	FlyBaseID:	FBgn0050203	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	934	Identity:	365/934 - (39%)
Similarity:	498/934 - (53%)	Gaps:	153/934 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLALVGVIPRIEG-CIRVPPGVTAAKSPVDDNYVLSVNGNTQSYVPGQRYNVSLSAFSGLSFIS 72
            :||.|:.  ..:.| |.|:|.|.:..:||||||:.:.::||.::|||..:||||||....:.|:|
  Fly     6 VLLILLS--SEVRGVCNRIPQGASGPRSPVDDNFKILIDGNPETYVPEHQYNVSLSCPINMKFVS 68

  Fly    73 FMLALDLESGDGD-GDANALGTWEIADLAETRFSPRCPNLVENTNTNVKTRVDVFWVAPSSPGQG 136
            |.|.::.|..... |..:..|.:|:..:.:||||..|.|:|||||||.|..:.|.|:||.:|..|
  Fly    69 FTLVVEAEDPSAAFGGQDMTGHFELLGVGDTRFSTSCENMVENTNTNAKIYIAVSWIAPRNPDSG 133

  Fly   137 CILLRATVMQHRDVWFMDDGFLTKRMCEEEVDDIDTQPSIVDPCCACDEAKYELTFEGKWSRHTH 201
            |:|::|.|:|||||||:||||||||:|.||:|::::....::.||||||||||:..|.||:|:||
  Fly   134 CVLIKAGVVQHRDVWFLDDGFLTKRICPEEIDELNSLTPPLETCCACDEAKYEIVLERKWARNTH 198

  Fly   202 PKDFPANSWRTRFSDIIGASHTLDYRFWQYGELASEGLREVAEHGSTRTLESELKD--QSEHIRT 264
            .||||:..||||..::|||||:..||:|.||..||:|::|:||||:|||||:|:::  |:..:||
  Fly   199 WKDFPSEDWRTRLGEVIGASHSHSYRYWAYGGRASKGMKELAEHGATRTLENEIRENTQNGEVRT 263

  Fly   265 IIKARGIAY-PNVTGKTFAVFRVDSNHHLISLVSMVDPSPDWIVGVSGLELCLPNCSWVENKVHN 328
            ||||.||.| |...|.|.|..|:|..||.|||.:.:|||||||:||:||||||.||:|:|.||.|
  Fly   264 IIKAPGIPYRPKTFGTTLANARLDPVHHQISLAAKIDPSPDWILGVAGLELCLSNCTWLERKVLN 328

  Fly   329 LYPWDAGTDSGPSYMSADQPQVPPDVVRRIKSNFPNDPRSPFYDPTGAQMKPLATLHINRRRLYE 393
            |||||.||||||||||:|:|||||||||||.|::|:|.||||||.|||.|||||||::.|::||.
  Fly   329 LYPWDIGTDSGPSYMSSDEPQVPPDVVRRITSSYPSDHRSPFYDDTGAPMKPLATLYLTRKKLYI 393

  Fly   394 KNCESSDSEQVPPECATNSWSRWDECTTKCGPGKQYRIREFKNPALASRHRCNNALREEKNCVGH 458
            :.||....|. |.|||.:.|:.|..|:|:||.|..:|.|.||||.||:...|:..|.|.:.|.|.
  Fly   394 RECEEVPQEG-PLECAVHPWNEWTNCSTRCGQGYSHRQRSFKNPNLAANFNCDRRLEEFRQCQGT 457

  Fly   459 KCAGFNEETAEGGEP----EVAPSPGSSDDPQCGLSDWSEWSSCTVTCGTGEMTRSRHYLNKKAK 519
            :| |..||..||.||    |..||.||.  .:|.|::|.|||.||.|||.|..||:|.|.|.:|:
  Fly   458 QC-GAAEEELEGEEPGLGMENPPSSGSM--AECQLTNWGEWSPCTKTCGRGSSTRTRDYYNPQAR 519

  Fly   520 KKCQKASRARLHETKICEAMECGGDIENEGGA-GEPEEEQAG-GDGGGSAEKRSIFRNFESYSQ- 581
            ::|....|..|.||:.|...:|||.|.:.|.. |.||.:..| .|.||...|.:.:.:.:.:|.
  Fly   520 QRCLSVMRIPLEETRECIGSDCGGTIPDNGELDGFPEPDVFGETDHGGYMGKTTSWNSKQEHSSL 584

  Fly   582 -------HREDYIPPVCGVTPWSDFS------------------------PCMGP---CGGHGK- 611
                   :|:.|       ..|.|.|                        |...|   .||:.|
  Fly   585 GSGNQAWNRKPY-------NSWKDKSLSNPRDNAQESPNLPFDQIENPQRPAYNPSDNMGGYDKG 642

  Fly   612 ------------------RQRIRKVWNNNQVYG-VTDPNDDGQDP--CRHIKLHEEV----NCTN 651
                              .......:||...|. .|.|:...:.|  .|:....|.|    |..|
  Fly   643 FPPTNSYSNDKLVGNRPGYNDFNSDYNNKDAYNDYTTPSFTSRTPFGSRYPNQQETVEGNTNDIN 707

  Fly   652 PSCDTIVPGFCYDE--LTDSPCRDNDV--ANFWYYDHVSDQCAIYWSDRCDTNRNKFKSKEECEE 712
            .:.: :|..:|:::  .:..||....|  :|:|:|||...:|.|:.:|.||.|||:|::...||.
  Fly   708 GNYN-VVQDYCFEKPYASTLPCFAKPVVESNYWFYDHEDHECKIFTTDNCDQNRNRFRTLTACEG 771

  Fly   713 TCRLP-----------------RHKQELQHDGIPAIDCLVSDWVS---------HSCNASCGDGF 751
            ||..|                 |...:.|..|.|      .|..|         .|.:...|..:
  Fly   772 TCLQPQINMERSENDAMDLYGRRSYDQKQTRGRP------YDQTSGIAYGQTEGRSYDQKVGKSY 830

  Fly   752 QLRTRRVLRTPKYGGKPCPKHLVRLDRCY---------QRCDDMYSIS----------------- 790
            .....|..:....|....|:     ||.|         |..|..|.:|
  Fly   831 DRTFGRSYKQTGGGSYDQPE-----DRSYDLSTGRSYVQPEDRSYDLSRGRSYDQPVGRSYDLAG 890

  Fly   791 GRGFGERRHVVRAPQPEPQDECRY 814
            ||.:||........:|..|...||
  Fly   891 GRSYGETSEAGDIGEPMSQTRSRY 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17739	NP_610757.1	Reeler	23..163	CDD:260081	68/140 (49%)
		Spond_N	186..373	CDD:283999	120/189 (63%)
		TSP1	412..460	CDD:214559	20/47 (43%)
		TSP1	490..541	CDD:214559	22/50 (44%)
		KU	661..715	CDD:294074	21/57 (37%)
		TSP_1	815..862	CDD:278517	365/934 (39%)
CG30203	NP_725128.2	Reeler	18..160	CDD:260081	68/141 (48%)
		Spond_N	183..372	CDD:283999	119/188 (63%)
		TSP1	411..459	CDD:214559	20/47 (43%)
		TSP1	492..541	CDD:214559	22/48 (46%)
		KU	<739..773	CDD:197529	15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438636
Domainoid	1	1.000	186	1.000	Domainoid score	I3283
eggNOG	1	0.900	-	-		E1_KOG3539
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2015
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	P	PTHR11311
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
	10	9.800