Protein Alignment CG17739 and Spon1

DIOPT Version :10

• Sequence 1: NP_610757.1
• Gene: CG17739 / 36333
• FlyBaseID: FBgn0033710
• Length: 873
• Species: Drosophila melanogaster
• Sequence 2: NP_663559.1
• Gene: Spon1 / 233744
• MGIID: 2385287
• Length: 807
• Species: Mus musculus
• Alignment Length: 898
• Identity: 287/898 - (31%)
• Similarity: 420/898 - (46%)
• Gaps: 179/898 - (19%)

  Fly    17 IPRIEG-CIRVPPGVTAAKSPVDDNYV---LSVNGNTQSYVPGQRYNVSLSAFSGLSFISFMLAL 77
            :.:.|| |.|    :..|:....:.|.   |.|.|:...|.||..|.|:|||.....|..|.|..
Mouse    37 VTKSEGYCSR----ILRAQGTRREGYTEFSLRVEGDPDFYKPGSSYRVTLSAAPPSYFRGFTLIA 97

  Fly    78 DLESGDGDGDANALGTWEIADLAETRFSPRCPNLVENTNTNVKTRVDVFWVAPSSPGQGCILLRA 142
            ..|:.:||.:.:..||::|.|..||:|...||..|..:....:||:.|||:||.: |.||::|:|
Mouse    98 LKENQEGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPT-GTGCVILKA 161

  Fly   143 TVMQHRDVWFMDDGFLTKRMCEEE--VDDIDTQPSIVDPCCACDEAKYELTFEGKWSRHTHPKDF 205
            :::|.|.::|.|:|.|||::||::  :|.:..:| |:| ||||..|||.|||.|.||..|||||:
Mouse   162 SIVQKRIIYFQDEGSLTKKLCEQDPTLDGVTDRP-ILD-CCACGTAKYRLTFYGNWSEKTHPKDY 224

  Fly   206 P--ANSWRTRFSDIIGASHTLDYRFWQYGELASEGLREVAEHGSTRTLESELKDQSEHIRTIIKA 268
            |  ||.|    |.|||.||:.:|..|:||..||||:::|||.||...:|.|::.||:.:.|:|||
Mouse   225 PRRANHW----SAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKA 285

  Fly   269 RGIAYP-----NVTGKTFAVFRVDSNHHLISLVSMVDPSPDWIVGVSGLELCLPNCSWVENKVHN 328
            :. .:|     ||.....|.|.||...||:|.::|:.|||||.||:|..:||...|.||:..|.:
Mouse   286 KA-QWPAWQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQD 349

  Fly   329 LYPWDAGTDSGPSYMSADQPQVPPDVVRRIKSNFPNDPRSPFYDPTGAQMKPLATLHINRRRLYE 393
            |.|||||||||.:|.|.::|.:|.:.:|.:.|  .:.|:||||||.|..:..:|.:.|.|.....
Mouse   350 LIPWDAGTDSGVTYESPNKPTIPQEKIRPLTS--LDHPQSPFYDPEGGSITQVARVVIERIARKG 412

  Fly   394 KNC----------------ESSDSEQVPPECATNSWSRWDECTTK-CGPGKQYRIREFKNPALAS 441
            :.|                |..|.:..|..|..::||.|..|::. |..||:.|.|..| ..|..
Mouse   413 EQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQRMLK-AQLDL 476

  Fly   442 RHRCNNALREEKNCVGHKCAGFNEETAEGGEPEVAPSPGSSDD--PQCGLSDWSEWSSCTVTCGT 504
            ...|.:. ::.:.|:|                     ||.||:  ..|.:|:|..||.|:|:||.
Mouse   477 SVPCPDT-QDFQPCMG---------------------PGCSDEDGSTCTMSEWITWSPCSVSCGM 519

  Fly   505 GEMTRSRHYLNKKAKKKCQKASRARLHETKICEAMECGGDIENEGGAGEPEEEQAGGDGGGSAEK 569
            |..:|.|:     .|:..:..|...|                       |.||         .||
Mouse   520 GMRSRERY-----VKQFPEDGSVCML-----------------------PTEE---------TEK 547

  Fly   570 RSIFRNFESYSQHREDYIPPVCGVTPWSDFSPCMGPCG-GHGKRQRIRKVWNNNQVYGVTDPNDD 633
            .::          .|:..|..|.||.|.::..|...|| |..||.|:.|:          .|.|.
Mouse   548 CTV----------NEECSPSSCLVTEWGEWDDCSATCGMGMKKRHRMVKM----------SPADG 592

  Fly   634 GQDPCRHIKLHEEVNCTNPSCDTIVPGFCYDELTDSPCRDNDVANFWYYDHVSDQCAIYWSDRCD 698
            ..  |: .:..:...|..|.|.||            ||    :.:.|  ...|| |::.......
Mouse   593 SM--CK-AETSQAEKCMMPECHTI------------PC----LLSPW--SEWSD-CSVTCGKGMR 635

  Fly   699 TNRNKFKS-------KEECE--ETCRLPRHKQELQHDGIPAIDCLVSDWVSHS-CNASCGDGFQL 753
            |.:...||       .|:.|  |.|.||.         .| |||.:|:|...| ||.|||.|..:
Mouse   636 TRQRMLKSLAELGDCNEDLEQAEKCMLPE---------CP-IDCELSEWSQWSECNKSCGKGHMI 690

  Fly   754 RTRRVLRTPKYGGKPCPKHLVRLDRCYQRCDDMYSISGRGFGERRHVVRAPQPEPQDE------C 812
            |||.:...|::||.|||:.:.|.....::|....|:....:.|.|...|:.|...:.:      |
Mouse   691 RTRTIQMEPQFGGVPCPETVQRKKCRTRKCLRSPSVQKLRWREARESRRSEQLREESDGEQFPGC 755

  Fly   813 RYSEWSAWTPCTATCGDNAVRQRTRTLMNTDLSYK---CKDRVRMEKCVMMPC 862
            |...|:||:.||..|| ..:::|..|:.....|.:   |||:..:..|.:.||
Mouse   756 RMRPWTAWSECTKLCG-GGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17739	NP_610757.1	Reeler	23..163	CDD:260081	51/142 (36%)
		Spond_N	186..380	CDD:461924	94/200 (47%)
		TSP1_spondin	487..>512	CDD:480609	11/24 (46%)
		TSP1	490..541	CDD:214559	14/50 (28%)
		TSP1_spondin	591..654	CDD:480609	17/63 (27%)
		Kunitz-type	662..714	CDD:444694	12/60 (20%)
		TSP1_spondin	733..>773	CDD:465948	19/40 (48%)
		TSP1_spondin	812..862	CDD:480609	16/52 (31%)
Spon1	NP_663559.1	TSP1_spondin	669..720	CDD:465948	20/50 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..752		4/19 (21%)
		TSP1_spondin	755..807	CDD:465948	16/52 (31%)
		Reeler	43..182	CDD:260081	51/143 (36%)
		Spond_N	205..397	CDD:461924	94/198 (47%)
		TSP1_spondin	443..494	CDD:465948	16/73 (22%)
		TSP_1	505..554	CDD:459668	20/95 (21%)
		TSP_1	562..610	CDD:459668	15/60 (25%)
		TSP_1	618..665	CDD:459668	13/58 (22%)