DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17739 and spon-1

DIOPT Version :9

Sequence 1:	NP_610757.1	Gene:	CG17739 / 36333	FlyBaseID:	FBgn0033710	Length:	873	Species:	Drosophila melanogaster
Sequence 2:	NP_495473.2	Gene:	spon-1 / 174169	WormBaseID:	WBGene00006893	Length:	819	Species:	Caenorhabditis elegans

Alignment Length:	918	Identity:	268/918 - (29%)
Similarity:	426/918 - (46%)	Gaps:	173/918 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALEGFTILLALVGVIPRIEG-CIRVPPGVTAAKSPVDDNYVLSVNGNT-------QSYVPGQRYN 59
            |:..|.:||.|:......|. |...|......|||..:.||:.:||.|       :.:|||:.|.
Worm     6 AILQFILLLLLIFSCNADEAKCTIKPYEAKGDKSPGSNGYVIEINGTTTKSMDISKGFVPGEIYK 70

  Fly    60 VSL----SAFSGLSFISFMLALDLESGDGDGDANALGTWEIA-DLAETRFSPRC-PNLVENTNTN 118
            ||:    :.::..:|..|:::...|      |..:.|:|::. ...:.|.||.| .:.|.:.|..
Worm    71 VSIRGWRTQYTVKTFRGFVVSSLFE------DNTSAGSWQVVKGHGDARISPGCRQSGVSHANLK 129

  Fly   119 VKTRVDVFWVAPSSPGQGCILLRATVMQHRDVWFMDDGFLTKRMCEEE-------VDDIDTQPSI 176
            .||.|.:.|.|| ....||::.||:|::.:.:||.:...||.::|.::       |||    ||.
Worm   130 SKTSVHMMWKAP-EVSSGCVVFRASVIETKYIWFTEAEGLTVKLCIQKGTQILKPVDD----PSA 189

  Fly   177 VDPCCACDEAKYELTFEGKWSRHTHPKDFPANSWRTRFSDIIGASHTLDYRFWQYGELASEGLRE 241
            .  |||||.|:|:|.|.|.||::|||||:|.....|.|:|::|:||:.:|..|..|.::::|::|
Worm   190 T--CCACDIAQYDLEFTGIWSKNTHPKDYPTLEHLTHFTDMLGSSHSSNYSLWTIGGISTDGMKE 252

  Fly   242 VAEHGSTRTLESELKDQSEHIRTIIKARGIAYPNVTGKTFAVFRVDSNHHLISLVSMVDPSPDWI 306
            :||.|:|...|:|.|.::..:|:::|.:|:.:|:|.|.|.:.|.|:..||.:||.:|..|||||.
Worm   253 IAEWGNTYKAEAEAKAKASEVRSLMKVKGLWFPDVQGTTKSQFVVNKYHHFVSLATMFGPSPDWC 317

  Fly   307 VGVSGLELCLPNCSWVENKVHNLYPWDAGTDSGPSYMSADQPQVPPDVVRRIKSNFPNDPRSPFY 371
            ||:|.:.||||:|:|.|.:...|.|:||||||||:|||.::|..|.:.:..|.:..  :|.||||
Worm   318 VGLSSVNLCLPDCTWAEERTFELQPFDAGTDSGPTYMSPNEPTEPREPIHWITTKL--NPLSPFY 380

  Fly   372 DPTGAQMKPLATLHINRRRLYEKNCESSD------------SEQVP----PECATNSWSRWDECT 420
            :.....:..||.:.:.|:.:....|:|.|            ||...    .||....|..|..|:
Worm   381 NSKSDTIPTLAKVILRRKNVTSSECKSDDILKAEAHNITNTSEDEEYKDRRECMMTQWEPWSLCS 445

  Fly   421 TKCGPGKQYRIREFKNPALASRHRCNNALREEKNCVGHKCAGFNEETAEGGEPEVAPSPGSSDDP 485
            ..||.|.:.|.|.:..|..|....|:....|::.|        |.:..|....|...|
Worm   446 ATCGKGIRIRSRVYVFPIKAQVFHCHRQTTEKQFC--------NAKINECENSEAFSS------- 495

  Fly   486 QCGLSDWSEWSSCTVTCGTGEMTRSRHYLNKKAKKKCQKASRARLHETKICEAMECGGDIENEGG 550
            :|.:|.|..|..|:|.||.|..:|:|.:||...|                  :.:|..|:|
Worm   496 KCQVSSWGSWGECSVQCGHGMRSRNRTFLNPATK------------------SGDCSVDLE---- 538

  Fly   551 AGEPEEEQAGGDGGGSAEKRSIFRNFESYSQHREDYIP-PVCGVTPWSDFSPCMGPCGGHGKRQR 614
                .::...|:.|...                 :..| |:|..|.|||:|||...| ..|.|.|
Worm   539 ----RKDICVGENGDDC-----------------NVTPDPLCKTTAWSDWSPCSASC-DEGVRVR 581

  Fly   615 IRKVWNNNQVYGVTDPNDDGQDPCRHIKLHEEVNCTNPSCDTIV----PGFCYDELTDSPCRDND 675
            .|..:.:           :.:..|.|:.|.|:..|...||...:    ...|.::.....|..|
Worm   582 TRLFFYS-----------EHEKRCMHVNLQEKDTCVMQSCRRFIEINSEEICQEDKQAGQCAGN- 634

  Fly   676 VANFWYYDHVSDQCAIYWSDRCDTNRNKFKSKEECEETCRLPRHKQELQ---------------- 724
            ...:| |:|...||..:....|..|||:|:::|||::.| ||.:::...
Worm   635 FPRYW-YNHEKTQCERFIFTGCKGNRNQFETEEECKQIC-LPGYEKSKSLIPNNQLLEDFGNTEV 697

  Fly   725 HDGIPAIDCLVSDWVS-HSCNASCGDGFQLRTRRVLRTPKYGGKPCPKHLVRLDRCYQRCDDMYS 788
            .||...:||.||.|.: .||:.|||.|.:.|:|.|::..:.||..|.:||::..:|..|
Worm   698 DDGGERVDCEVSKWTAWGSCSVSCGRGKKSRSRHVVKLARNGGHQCSEHLMQELQCRLR------ 756

  Fly   789 ISGRGFGERRHVVRAPQPEPQDECRYSEWSAWTPCTATCGDNAVRQRTRTL--MNTDL-SYKCKD 850
                           |.| .:..|:...||.|:||:.:||:.:..:|.|.:  .|.|. ..:|.|
Worm   757 ---------------PCP-VKLTCQVGPWSRWSPCSVSCGEGSQTRRRRVVRARNDDWEEIECDD 805

  Fly   851 -RVRMEKC 857
             ...:.:|
Worm   806 AETEVRQC 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17739	NP_610757.1	Reeler	23..163	CDD:260081	43/152 (28%)
		Spond_N	186..373	CDD:283999	81/186 (44%)
		TSP1	412..460	CDD:214559	13/47 (28%)
		TSP1	490..541	CDD:214559	13/50 (26%)
		KU	661..715	CDD:294074	16/53 (30%)
		TSP_1	815..862	CDD:278517	14/47 (30%)
spon-1	NP_495473.2	Reeler	36..171	CDD:260081	41/141 (29%)
		Spond_N	197..381	CDD:283999	80/185 (43%)
		TSP1	435..481	CDD:214559	13/53 (25%)
		TSP1	499..551	CDD:214559	18/77 (23%)
		TSP1	562..610	CDD:214559	17/59 (29%)
		Kunitz_BPTI	621..672	CDD:278443	16/52 (31%)
		TSP1	708..759	CDD:214559	20/71 (28%)
		TSP1	766..816	CDD:214559	14/48 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156310
Domainoid	1	1.000	210	1.000	Domainoid score	I1641
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46443
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	1	1.000	-	-		otm14588
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	LDO	PTHR11311
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3762
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.750