DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salto and myo-5

DIOPT Version :9

Sequence 1:	NP_610756.2	Gene:	salto / 36332	FlyBaseID:	FBgn0061197	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_505094.1	Gene:	myo-5 / 179190	WormBaseID:	WBGene00019064	Length:	1974	Species:	Caenorhabditis elegans

Alignment Length:	896	Identity:	181/896 - (20%)
Similarity:	334/896 - (37%)	Gaps:	243/896 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 IHSRKTSLERVTSSTKARPCVSTYSLPNRRVEPEHKVV------EPDRKTDIDELNPPKRNVVPI 134
            :...||..||.....:|.         |.|:|.|.:.:      |.|...:.:|.:        .
Worm   869 LEEEKTQEERKRKDMEAE---------NARLEAEKQALLIQLEQERDSSAEGEERS--------A 916

  Fly   135 KTHAQSAQLVKSTT------CEPYQNVKKPEKMSHRRVLEMNR------MRVFDTQKKKLENLQS 187
            |..||.|.|.|...      |:  :..|.......::.:|.:.      :...:|..||.|:.:.
Worm   917 KLLAQKADLEKQMANMNDQLCD--EEEKNAALTKQKKKIEQDNEGLKKTVSDLETTIKKQESEKQ 979

  Fly   188 EFMHKIRLMGSELRNQGVFKFVGLTVNDECKLVVHHDDLLR-LPKSIPAES-----MNDLKTRCR 246
            ...|:||.:..|:::|..   |...:|.|.|   |.:::.| |.:.|.||.     :|..|.:..
Worm   980 AKDHQIRSLQDEIQSQDE---VISKLNKEKK---HQEEVNRKLLEDIQAEEDKVNHLNKTKAKLE 1038

  Fly   247 AIVDQGVLLIYDHIPRIQRAKNDLEASEKREETQKKLSNLVEEKMNLIVEEIEQLC--------- 302
            :.:|:    :.|.:.|.:|.:.|.|...::.|.:.|::..:.|::|....|.||:.
Worm  1039 STLDE----LEDTLEREKRGRQDCEKQRRKVEGELKIAQELIEELNRHKHEQEQVIKKKDIELSS 1099

  Fly   303 --GACSKQESPNKSLYREMSELRSQKQAMEVRYFDAQKEHTEQMNQLRIELDAKLKQ------EL 359
              .....::|....|.|::.||.::.|.:| ...||::....:..:.|.|:..:|::      |.
Worm  1100 IQSRLEDEQSLVAKLQRQIKELLARIQELE-EELDAERNSRSKAEKARNEMQMELEELGDRLDEA 1163

  Fly   360 ASRDQIIVELRK-------SLRRS-ED--MLSEQS---IRLAENN--SKLLTEDSTIEVLRSEVA 409
            ....|..:||.|       .||:. ||  :.||.|   :|...|:  ::|..:..||:.:|.::.
Worm  1164 GGATQAQIELNKKREAELAKLRQDLEDAAINSETSMAALRKKHNDAVAELSDQLDTIQKMRGKLE 1228

  Fly   410 KLKTVKEQMVKRLEEADKGLERARNSVDKNLKHIDYLEGELKEARELIVHLEQRPDAMDAGVKEK 474
            :.|..|::.|..|:::.....:.|.:.::..|.   ||.:|.:              |.....|:
Worm  1229 REKNDKQREVDELQQSADVEAKQRQNCERMAKQ---LEAQLTD--------------MTLKSDEQ 1276

  Fly   475 DLIIADLKLQLQSLEQHKKVMNKQV---------ANTIK--QHADFEELGGNYKEALQQISDLRE 528
            ..:|.:|.:....:....:.:|:|:         .|.||  ||:..|||    |..|.|.:..|:
Worm  1277 ARLIQELTMGKNKVHNENQDLNRQLEDAEAQLCALNRIKQQQHSQLEEL----KRTLDQETRERQ 1337

  Fly   529 TL--SVTNAKLEMQSKLEVQLRKEVSKMREQMV-IDQKLLNARSELIATLQKNE----------E 580
            :|  .|:|.:||.:     |.|:.:.:.::... :.::|..|.||:.....|.|          |
Worm  1338 SLHSQVSNYQLECE-----QFRESLEEEQDAKTDVQRQLSKANSEIQQWRAKFEGEGVSRAEELE 1397

  Fly   581 DSRTKLDQMYYQVSEKETLINQVNNKLSSKEEEFYNLYGTLTHKQREVRRQEHIIKLLK------ 639
            ::|.||.   ::|.|.:..:...|.|:.:.|:....|...|...|.:..|...|...|:
Worm  1398 ETRRKLT---HKVQEMQEQLENANQKIGTLEKNKQRLAHDLEDAQVDADRANSIASSLEKKQKGF 1459

  Fly   640 ------------------EQNSRVSLLRA-------NQDERNATMEEEIKHLKNALRNYAKLIVG 679
                              ||:.|.:...|       ||.|.:....|.:|....||....|.|..
Worm  1460 DKVLDEWRRKCEALVAEVEQSQRETRAAATETFRLRNQLEESGEQTEAVKRENKALAQELKDIAD 1524

  Fly   680 NMGEHFFEVLPAGEMESIRSGGHPV--------RVDSSCKFLQEP--------NLQEPNLQEPNL 728
            .:||                ||..|        |::...:.||:.        ..:|..:....:
Worm  1525 QLGE----------------GGKSVHDLQKMRRRLEIEKEELQQALDEAECALEAEEAKVMRAQI 1573

  Fly   729 QEPNLQDDTLQEPNLQEPNLQEPNLQEPNLQDAILQEPNLQ------------------EPNLQD 775
            :...::.:.  |..|||...:..|.::.:.:.....:.:|:                  :.|..:
Worm  1574 EVSQIRSEI--EKRLQEKEEEFENTRKNHSRTIESMQVSLETESRGRAELLKTKKKLEGDVNELE 1636

  Fly   776 ATLQEPN------------LQDATLQELNLQDATLQEPNLQEQEMSQPRGR 814
            ..|...|            ||| |::||..|        ::|::.|....|
Worm  1637 IALDHSNKLNVDGQKSMKKLQD-TIRELQYQ--------VEEEQRSLSESR 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salto	NP_610756.2	DUF1640	<313..422	CDD:285090	32/129 (25%)
		BAR	<518..670	CDD:299863	40/195 (21%)
		YjbI	<713..803	CDD:224276	19/127 (15%)
myo-5	NP_505094.1	Myosin_N	31..68	CDD:280832
		Myosin_head	83..776	CDD:278492
		MYSc_class_II	95..776	CDD:276951
		Myosin_tail_1	853..1933	CDD:279860	181/896 (20%)
		DUF4795	954..1129	CDD:292662	41/184 (22%)
		Prefoldin	1111..1243	CDD:298833	33/132 (25%)
		Tmemb_cc2	<1212..1322	CDD:287269	24/126 (19%)
		DUF881	1746..>1838	CDD:303034
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000