Protein Alignment CG8850 and SLC6A5

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 222/632 - (35%)
• Similarity: 345/632 - (54%)
• Gaps: 53/632 - (8%)

  Fly    27 SNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENG 91
            :.|||::|:..:.....|...|...|:.. |..||..::|:.|.:..:||||||||||::|.:||
Human   162 ATDGITSVLPGSVATVATQEDEQGDENKA-RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNG 225

  Fly    92 GGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACI 156
            ||||||||:::|.|.|.|:::|||.:|||:|:|.:..:...|.::|.....:..:.|...||..|
Human   226 GGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVI 290

  Fly   157 MALTIRYLVASFSEVLPWTYCLVEWG------------KSCVAT------------------GAT 191
            :..|:.||.|||..||||..|...|.            .|||.:                  ..|
Human   291 ICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVT 355

  Fly   192 AANDSSIVQG--VSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSS 254
            ..|.:|....  ||.:|.:|...||:....::..  |...|.|.|||...|||:...|:|||::|
Human   356 MVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYP--GEIRWPLALCLFLAWVIVYASLAKGIKTS 418

  Fly   255 GKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFG 319
            ||..||.|.||||::::||||.||||||..||.||:.|:|.:|.:..||..|.||:||||:..:|
Human   419 GKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWG 483

  Fly   320 TLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAF 384
            .|:..:|:|.|:.|.::|.:|:|..:|.|||.||.:||.::|.:|.|... :|..|...|.|:||
Human   484 GLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVADQGPGIAF 547

  Fly   385 ISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF-----THLPHWLLAVSA 444
            :.||||:.:....| .:|::||.|||.||:.:.......:|..:.|.|     ||.|  :..:..
Human   548 VVYPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKP--VFTLGC 609

  Fly   445 SIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTS 509
            .|..|:.|...:|.||.::..|||.|..::..:::||.||:.:.::||::|.|.|||.|:..:.:
Human   610 CICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPN 674

  Fly   510 FYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQ 574
            .:|::|||.|.|.::..:|.:..:.:||:||...:||....:.||::....|:.:|...::.::.
Human   675 IFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHL 739

  Fly   575 QPGKTFGSKFGLAMQPTANWGPLQTQKFEAYIIHR-KREADFKSPRG 620
            .||: |..:..|...|..:|||...|       || :|..:...|.|
Human   740 APGR-FIERLKLVCSPQPDWGPFLAQ-------HRGERYKNMIDPLG 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	190/510 (37%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	215/602 (36%)