Protein Alignment CG8850 and Slc6a2

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_112633.2
• Gene: Slc6a2 / 83511
• RGDID: 621822
• Length: 617
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 201/556 - (36%)
• Similarity: 305/556 - (54%)
• Gaps: 27/556 - (4%)

  Fly    28 NDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGG 92
            ::|:..::.|.:|:            :..|:.|.:.::||.|.:..:|.|.||||||::..:|||
  Rat    39 HNGVQCLLASQDGD------------AQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGG 91

  Fly    93 GAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIM 157
            |||||||.:.|::.|.|::|:|:.:|||:..|....:.:.|..:|:.|..:........||..|:
  Rat    92 GAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVII 156

  Fly   158 ALTIRYLVASFSEVLPWTYCLVEWGK-SCV---ATGATAANDS---SIVQGVSSAELFFTQTVLR 215
            |.::.||.|||:..||||.|...|.. :|.   ...|:...|.   |..:...:|| |:.:.||.
  Rat   157 AWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAE-FYERGVLH 220

  Fly   216 EPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLP 280
            ..||...:.:|.|.|.|:|||:...|::...|.||:::|||..:..|..||.::.|||:..||||
  Rat   221 LHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLP 285

  Fly   281 GAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTID 345
            ||..||..:|...:.:|....||..|.||:||||...||.|:.:||:|.|:.|.::|.::.:||:
  Rat   286 GASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTIN 350

  Fly   346 SLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLL 410
            .:||.::|..||.|||.:|.|...| |..|...||||.|:.|||||:.... ...:|||||.|||
  Rat   351 CVTSFISGFAIFSILGYMAHEHKVK-IEDVATEGAGLVFVLYPEAISTLSG-STFWAVLFFLMLL 413

  Fly   411 VLGIGSNIGMASAVVNVVKDRFTHLP-HWLLAVSASIIG-FLCGLVYMTPGGQFVLNLVDFYGCT 473
            .||:.|::|...||:..:.|.|..|. |..|...|..:| ||..:..:|.||.:||.|:|.:...
  Rat   414 ALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAG 478

  Fly   474 FIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPL 538
            ...|...:.|.:.|.|.|||.|..:||:.|:..|...|||:||..|:|..:..|:|..:.:::||
  Rat   479 TSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPL 543

  Fly   539 TYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQ 574
            ||....|||   .|.|:.||:.:..:.......||:
  Rat   544 TYDDYVYPP---WANWVGWGIALSSMILVPAYVIYK 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	184/482 (38%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:444915	198/527 (38%)