DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a19

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_083154.1	Gene:	Slc6a19 / 74338	MGIID:	1921588	Length:	634	Species:	Mus musculus

Alignment Length:	621	Identity:	184/621 - (29%)
Similarity:	307/621 - (49%)	Gaps:	101/621 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HPGSNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIAL 88
            :||..:.|.::      :||.:   .|.|.:|.|.:|....:::.:|:...||||||||||::..
Mouse     8 NPGLEERIPSL------DELEV---IEKEEAGSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQ 63

  Fly    89 ENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTY 152
            .:|||||:||::|:|:..|.|:.|||..|||...:|.:..: .:.|.::||....::.:.:...|
Mouse    64 SHGGGAFMIPFLILLVFEGIPLLYLEFAIGQRLRKGSMGVWSSIHPALKGIGIASMFVSFMVGLY 128

  Fly   153 YACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGVSSAELFFTQTVLREP 217
            |..|:|..:.|...||.|.|||:.|.:...:    ||.......|     ||.:.|:.:..|...
Mouse   129 YNTIIAWVMWYFFNSFQEPLPWSECPLNQNQ----TGYVEECAKS-----SSVDYFWYRETLNIS 184

  Fly   218 ESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGA 282
            .|:.|:  |:..|.::|||...|.::...:.:||.::|||.|..:..|||::.:.|||.:||.||
Mouse   185 TSISDS--GSIQWWILLCLTCAWSVLYVCIIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGA 247

  Fly   283 WQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSL 347
            ..|||:...|..::|.||:.|..|..|:|:|.::.||.|:.::|:|..:.|...|.:|::.|:..
Mouse   248 TNGIVFLFTPNITELSNPNTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVINGF 312

  Fly   348 TSILAGCIIFGILGNLAFE--------------------------------------TN------ 368
            ||:.|..:::.|:|..|.|                                      ||
Mouse   313 TSVYAATVVYSIIGFRATERFDDCVNTNILTLINGFDLPEGNVTSENFEAYQQWCNATNPQAYAQ 377

  Fly   369 ----TKDISQVVK---GGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVN 426
                |.||:..:.   .|.|||||.:.|||.|....| |::||||.||..||:.|..|....||.
Mouse   378 LKFQTCDINSFLSEGVEGTGLAFIVFTEAITKMPVSP-LWSVLFFIMLFCLGLSSMFGNMEGVVV 441

  Fly   427 VVKDRFTHLPHW-------LLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAEL 484
            .::|.......|       |:.:...:|.|    ::....||:.|:|:|.:..:...|::|..|:
Mouse   442 PLQDLNITPKKWPKELLTGLICLGTYLIAF----IFTLNSGQYWLSLLDSFAGSIPLLIIAFCEM 502

  Fly   485 LAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLV------------LVYMLF--SY 535
            .||.::|||.|...|||||:..|.:.:|::.|.:|:|.:|.::            |:|.::  :|
Mouse   503 FAVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKTLMYSIWDPNY 567

  Fly   536 E--PLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWAL 569
            |  |.:.: :.||...|.....:.|:..|.:|.:|:
Mouse   568 EEFPKSQK-IPYPNWVYAVVVTVAGVPCLSIPCFAI 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	165/544 (30%)
Slc6a19	NP_083154.1	SLC5-6-like_sbd	32..612	CDD:294310	176/588 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810