DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and slc6a4b

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001170930.1	Gene:	slc6a4b / 664770	ZFINID:	ZDB-GENE-060314-2	Length:	591	Species:	Danio rerio

Alignment Length:	577	Identity:	195/577 - (33%)
Similarity:	314/577 - (54%)	Gaps:	32/577 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PGSNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALE 89
            |.:|.|     |::....:.|..|:       ||:||:.::||.|.|..:|.||||||||:|..:
Zfish    18 PPNNAG-----YNSNPVPVIIQTES-------RDKWSKKMDFLLSVIGFAVDLGNVWRFPYICYQ 70

  Fly    90 NGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYY 153
            |||||||||||::.:..|.|::|:|:.:|||...|.|..: .:.||.:||.:.........:.||
Zfish    71 NGGGAFLIPYVLMAVFGGVPLFYMELALGQFHRTGAISIWKHICPIFKGIGFAICIIALYVSFYY 135

  Fly   154 ACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCV----ATGATAANDSSIVQGVSSAELFFTQTV 213
            ..|:|..:.|..:|||..||||.|..:|. ::|.    ....|..|.|.     |.||.|:|:.|
Zfish   136 NTIIAWALFYFYSSFSSTLPWTSCDNDWNTENCTNYFGKDNVTWTNYSR-----SPAEEFYTRNV 195

  Fly   214 LREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVT 278
            |...||.....:|...|.|:|||...:.|:...|.||:::|||..:..|..|||::::|:||..|
Zfish   196 LAVHESSGLGNVGYIRWQLMLCLFLIFTIVYFSLWKGVKTSGKVVWVTATLPYVVLLILMIRGAT 260

  Fly   279 LPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITT 343
            |||||:|:|::|.|:|.:|....||..|..|:||||...||.|:..:|:|.|..|.::|.|:.:.
Zfish   261 LPGAWKGVVFYLNPKWEKLKETSVWVDAAAQIFFSLGPGFGVLLALSSYNPFTNNCYRDAIVTSL 325

  Fly   344 IDSLTSILAGCIIFGILGNLAFE--TNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFF 406
            ::.|||.::|.:||.:||.:|.:  .|.:|:::  ..|..|.||:||||||.. .....||::||
Zfish   326 VNCLTSFVSGFVIFTVLGYMAEQRNVNVEDVAR--DKGPSLLFITYPEAIANM-VGSTFFAIIFF 387

  Fly   407 FMLLVLGIGSNIGMASAVVNVVKDRFTH-LPH--WLLAVSASIIGFLCGLVYMTPGGQFVLNLVD 468
            .|::.||:.|..|...|::..|.|.:.. |.|  .|..:...::.||..|..:|.||.:|:.|::
Zfish   388 VMMITLGLDSTFGGLEAIITAVMDEYPDVLSHRRELFVLGLVVVCFLGSLSTLTKGGAYVVKLLE 452

  Fly   469 FYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLF 533
            .:|.....:.:...|..||.|.||:.|..:||:.||......:|::||..::|..:..:::..|.
Zfish   453 EFGVGSSIIAIVFLEATAVSWFYGINRFSNDIKSMLGYTPGLFWKVCWVAISPAFLAYIIISSLL 517

  Fly   534 SYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQP 590
            :.:.||....::|......|:||.....:.:|.:.:..:...|| :...:..:.::|
Zfish   518 NPQTLTLFDYEFPDWSITVGYIIGASSFIWIPIYMVYKLVWTPG-SLKQRLAVCLRP 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	177/484 (37%)
slc6a4b	NP_001170930.1	SLC6sbd_SERT	38..574	CDD:271399	189/545 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820