Protein Alignment CG8850 and SLC6A12

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 209/594 - (35%)
• Similarity: 323/594 - (54%)
• Gaps: 42/594 - (7%)

  Fly    39 EGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVL 103
            |||:|.   :.:.:....|.||:..:||:.|.....:|||||||||::..:||||||.|||.|..
Human    21 EGEKLD---QEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFF 82

  Fly   104 LLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVAS 167
            .:.|.||::|||.:||::|:|.:.|: .:.|:.:||....|...:....||..|:|..:.||.:|
Human    83 FVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSS 147

  Fly   168 FSEVLPWTYCLVEWG-KSCV--ATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPS 229
            |:..||||.|...|. :.|.  ...:.|...:......|....|:.:.||.....:.|  ||:..
Human   148 FTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHD--LGSLR 210

  Fly   230 WDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQW 294
            |:|.||||..|||....:.||::|:||..||.|.|||:::::||||.||||||:|||:|:|||..
Human   211 WELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDL 275

  Fly   295 SQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGI 359
            .:|.:|.||..|.||:|||.|||.|.|....|:|.::.|.:||.|.:..::|.||.:||.::|.|
Human   276 FRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSI 340

  Fly   360 LGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAV 424
            ||.::.|... .||:|.:.|.|||||::|:|:.... |.||::.|||.||:.||:.|.......:
Human   341 LGFMSQEQGV-PISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIMLIFLGLDSQFVCVECL 403

  Fly   425 VNVVKDRFTHLPHW--------LLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LA 480
            |....|.|   |..        ||.::.:::.:|.||..:|.||.::..|.|:|..:.|.|: |:
Human   404 VTASIDMF---PRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLS 465

  Fly   481 IAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQ- 544
            :.|::.:.|:||..|...:||.|:..:.....:|.|..:.|||.....::.|..|.||.|..|.
Human   466 LFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYV 530

  Fly   545 YPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTA----------------- 592
            |||..|..||.:....::.:|.:.::|:.:..| .|..:....:.|.:
Human   531 YPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG-PFRKRLRQLITPDSSLPQPKQHPCLDGSAGR 594

  Fly   593 NWGPLQTQK 601
            |:||..|::
Human   595 NFGPSPTRE 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	183/486 (38%)
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	200/547 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		4/28 (14%)