Protein Alignment CG8850 and SLC6A11

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_055044.1
• Gene: SLC6A11 / 6538
• HGNCID: 11044
• Length: 632
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 210/581 - (36%)
• Similarity: 323/581 - (55%)
• Gaps: 29/581 - (4%)

  Fly    13 NMQGAQGSREGH-PG---SNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIAL 73
            |.:.|:.:||.. ||   |:.|.:...:.....:..::         :|..|:..|||:.|....
Human    11 NGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVH---------ERGHWNNKVEFVLSVAGE 66

  Fly    74 SVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRG 137
            .:|||||||||::..:|||||||||||:..:..|.||::||..:|||:|.|.|..: .:.|:..|
Human    67 IIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEG 131

  Fly   138 IAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCVA-TGATAANDSSI-V 199
            |.|......|....||..|:|..|.||...|:..|||..|..||. ::||. .....:|.|.: :
Human   132 IGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSL 196

  Fly   200 QGVSSAEL-FFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLAL 263
            |..:|..: |:...||...:.::.  :|...|:|.|||||.|.|....:.||.:|:||..|..|.
Human   197 QNATSPVMEFWEHRVLAISDGIEH--IGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTAT 259

  Fly   264 FPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFN 328
            |||:::::||||.||||||.:||.::|.|..|:|.:|.||..|.||:|||.|||.|.|....|:|
Human   260 FPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYN 324

  Fly   329 DFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAK 393
            ::|.|.::|.|::..::|.||.:||..||.:||.:|:|... .|::|.:.|.|||||:||:|:..
Human   325 NYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGV-PIAEVAESGPGLAFIAYPKAVTM 388

  Fly   394 FKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHL-----PHWLLAVSASIIGFLCGL 453
            ....| |:|.|||.||:.||:.|......::|..|.|.:..:     ...||.::.|:|.:..||
Human   389 MPLSP-LWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGL 452

  Fly   454 VYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWA 517
            |.:|.||.::..|.|.|..:.:.|: :||.|.:.:||:||..|...:||.|:..:.....:.||.
Human   453 VMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWM 517

  Fly   518 IVAPGLMFLVLVYMLFSYEPLTYRGV-QYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPG 577
            |:.||:...:.::.|..|:||.|..: .||...|..||::....:|.:|.|..:|:::..|
Human   518 IMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEG 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	186/484 (38%)
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		8/29 (28%)
		SLC6sbd_GAT3	49..590	CDD:212077	202/534 (38%)