Protein Alignment CG8850 and SLC6A9

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_054194404.1
• Gene: SLC6A9 / 6536
• HGNCID: 11056
• Length: 712
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 196/619 - (31%)
• Similarity: 327/619 - (52%)
• Gaps: 65/619 - (10%)

  Fly    24 HPGSNDGISTVIYSAEGEELTINCEAESESSGQRDQ------WSRGVEFLFSCIALSVGLGNVWR 82
            |...|.|:...:.:.....:..|....||:: :|||      |...:||:.:.:..:||||||||
Human    62 HGAYNSGLLPQLMAQHSLAMAQNGAVPSEAT-KRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWR 125

  Fly    83 FPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTA 147
            ||::...||||||:.||.|:|:..|.|::::|:..|||:|:||:..:.::|:.:|:.||.:..:.
Human   126 FPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVST 190

  Fly   148 LATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCV----ATGAT-----AANDSSI---- 198
            ....||..::.:...|..:|.:.||||.||...|. ..|.    |:..|     ||..|::
Human   191 YIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLL 255

  Fly   199 ---VQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYF 260
               :|..|.:|.::...||:..:  |....|.....|:.||..:|:::...|.:|::||||..||
Human   256 NHSLQRTSPSEEYWRLYVLKLSD--DIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYF 318

  Fly   261 LALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYA 325
            .|.||||::.:|.:|.|||.||:.||:|:|.|||.::|...||..|.:|:|:||...:|.|:..|
Human   319 TATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMA 383

  Fly   326 SFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEA 390
            |:|.|:.|.::|.:||:..:..||:.||.:||.|||.:|..... |:|:|...|.||||::||||
Human   384 SYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGV-DVSRVADHGPGLAFVAYPEA 447

  Fly   391 IAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHLPHWLL------AVSASIIGF 449
            :......| |:::||||||::||:|:...:...:|..:.|...:  .|:|      .:..::.||
Human   448 LTLLPISP-LWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGN--EWILQKKTYVTLGVAVAGF 509

  Fly   450 LCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRI 514
            |.|:...:..|.:.|.|:|.|..:|..:|::....:|:.:|||.:....||:.||......:::|
Human   510 LLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQI 574

  Fly   515 CWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVL--QLPFWALVTIYQ--- 574
            ||..|:|.::||         :...:|.:...|:::.:   :....||  |||....|..:.
Human   575 CWRFVSPAIIFL---------QAQVHRRLPQNPLHFAS---LPERNVLLHQLPQRGGVPEHDPPT 627

  Fly   575 --QPGKTFGSKFGLAMQPTAN----------WGP 596
              .|.:|:|.:..:...|.|.          |.|
Human   628 PPSPARTYGPQVRVREVPRARRQRSPNPAPLWAP 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	174/502 (35%)
SLC6A9	XP_054194404.1	SLC5-6-like_sbd	84..586	CDD:444915	176/508 (35%)
		PHA03247	<615..676	CDD:223021	9/47 (19%)