Protein Alignment CG8850 and SLC6A8

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_005620.1
• Gene: SLC6A8 / 6535
• HGNCID: 11055
• Length: 635
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 219/626 - (34%)
• Similarity: 325/626 - (51%)
• Gaps: 70/626 - (11%)

  Fly    22 EGHPGSNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFI 86
            :|.|...||  .|.....|..|.:         ..|:.|:|.::|:.||:..:||||||||||::
Human    28 DGAPAKGDG--PVGLGTPGGRLAV---------PPRETWTRQMDFIMSCVGFAVGLGNVWRFPYL 81

  Fly    87 ALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATT 151
            ..:||||.||||||::.|:.|.|:::||:.:|||...|.|..:::.|:.:|:.|..:.......|
Human    82 CYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNT 146

  Fly   152 YYACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCV-------ATGATAAN---------DSSIV 199
            ||..::|....|||.||:..|||..|...|. ..||       ...|:.||         .|.::
Human   147 YYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVI 211

  Fly   200 QGVSSAELFFTQTVLREPESLDDNGLGTP---SWDLVLCLLATWVIIGTILSKGIRSSGKASYFL 261
            :       |:...|||.     ..||..|   :|::.|||||.||::...:.||::|:||..||.
Human   212 E-------FWENKVLRL-----SGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFT 264

  Fly   262 ALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYAS 326
            |.||||:::|||:|.|.||||..||:|:|||.||:|.:|.||..|.||:|||.||..|.|....|
Human   265 ATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGS 329

  Fly   327 FNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAI 391
            :|.||.|.:||.||:..|:|.||..||.::|.|||.:|.|... .||:|.:.|.|||||:||.|:
Human   330 YNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGV-HISKVAESGPGLAFIAYPRAV 393

  Fly   392 AKFKYLPQLFAVLFFFMLLVLGIGSN-IGMASAVVNVVKDRFTHLP-----HWLLAVSASIIGFL 450
            ......| |:|.|||||||:||:.|. :|:...:..::    ..||     .:...:|.::...|
Human   394 TLMPVAP-LWAALFFFMLLLLGLDSQFVGVEGFITGLL----DLLPASYYFRFQREISVALCCAL 453

  Fly   451 C---GLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFY 511
            |   .|..:|.||.:|..|.|:|..:...|: .|..|.:.|.|:||..|...||..|:..:...:
Human   454 CFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPW 518

  Fly   512 WRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMA-GWIIWGLGVLQLPFWALVTIYQQ 575
            .:.||:...|.:...:.::.:..||||.|......|.:..| ||......:|.:|...|..:.:.
Human   519 MKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRA 583

  Fly   576 PGKTFGSKFGLAMQPTANWGPLQTQKFEAYIIHRKREADFK 616
            .| |...::....||.  ||       ..::.:|.::||.:
Human   584 KG-TMAERWQHLTQPI--WG-------LHHLEYRAQDADVR 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	190/503 (38%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		219/626 (35%)
		SLC6sbd_CT1	52..621	CDD:271397	212/591 (36%)