Protein Alignment CG8850 and SLC6A3

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 195/568 - (34%)
• Similarity: 305/568 - (53%)
• Gaps: 14/568 - (2%)

  Fly    34 VIYSAEGEELT----INCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGA 94
            ::....|.:||    .|.......:..|:.|.:.::||.|.|..:|.|.||||||::..:|||||
Human    33 LVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGA 97

  Fly    95 FLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMAL 159
            ||:||::.:::.|.|::|:|:.:|||:..|....:.:.||::|:.:..:..:.....:|..|:|.
Human    98 FLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAW 162

  Fly   160 TIRYLVASFSEVLPWTYCLVEWGK-SCV-ATGATAANDSSIVQ---GVSSAELFFTQTVLREPES 219
            .:.||.:||:..|||.:|...|.. :|. |....::.|||.:.   |.:.|..:|.:.||...:|
Human   163 ALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQS 227

  Fly   220 LDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQ 284
            ...:.||.|.|.|..||:...|::...|.||:::|||..:..|..|||::..||:|.||||||..
Human   228 HGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAID 292

  Fly   285 GIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTS 349
            ||..:|...:.:|....||..|.||:.|||.:.||.|:.::|:|.|..|.::|.|:.|:|:||||
Human   293 GIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTS 357

  Fly   350 ILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGI 414
            ..:|.::|..||.:| :.::..|..|.|.|.||.||.||||||... |...:||:||.|||.|||
Human   358 FSSGFVVFSFLGYMA-QKHSVPIGDVAKDGPGLIFIIYPEAIATLP-LSSAWAVVFFIMLLTLGI 420

  Fly   415 GSNIGMASAVVNVVKDRF--THLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIAL 477
            .|.:|...:|:..:.|.|  .|....|..:...:..||..|..:|.||.:|..|:|.:......|
Human   421 DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSIL 485

  Fly   478 VLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRG 542
            ...:.|.:.|.|.|||.:...||:.|...:.|.|||:||.:|:|..:..|:|..:.::.|..|..
Human   486 FGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGA 550

  Fly   543 VQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQP 590
            ..:|......||:|....:..:|.:|.......|| :|..|...|:.|
Human   551 YIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPG-SFREKLAYAIAP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	176/480 (37%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	191/541 (35%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		8/29 (28%)