Protein Alignment CG8850 and SLC6A1

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 197/608 - (32%)
• Similarity: 317/608 - (52%)
• Gaps: 48/608 - (7%)

  Fly    29 DG-ISTVIYSA-----EGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIA 87
            || |||.:..|     :.:.|.:..:.::.....||.|....:||.||:..::|||||||||::.
Human    10 DGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLC 74

  Fly    88 LENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTY 152
            .:||||||||||.:.|:..|.|::.||..:||::|.|.:..:.:||:.:|:.......:.....|
Human    75 GKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIY 139

  Fly   153 YACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGVSSAELFFTQTVLREP 217
            |..|::..|.||..||:..|||..|...|......:..:..|.:::...|..   |:.:.:.:..
Human   140 YIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVE---FWERNMHQMT 201

  Fly   218 ESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGA 282
            :.||..  |...|.|.:.|...|:::...:.||:..:||..||.|.:||:::|:|..|.||||||
Human   202 DGLDKP--GQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGA 264

  Fly   283 WQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSL 347
            .:||::::.|.:.:|.:..||..|.||:|||..:..|:|:...|:|.|:.||::|.||:..|:|.
Human   265 KEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSC 329

  Fly   348 TSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVL 412
            ||:.||.:||.|:|.:|..|. :.|:.|...|.||||::||||:.:....| |:|:|||.|||:|
Human   330 TSMFAGFVIFSIVGFMAHVTK-RSIADVAASGPGLAFLAYPEAVTQLPISP-LWAILFFSMLLML 392

  Fly   413 GIGSNIGMASAVVNVVKDRFTHL---PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTF 474
            ||.|........:..:.|.:..|   ...|...:..||.:|.||..:|.||.:|..|.|:|..:.
Human   393 GIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASG 457

  Fly   475 IALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPL 538
            ::|: |...|.:::.|.|||.|...:|:.|:..:...:|::||:...|.::..|.::......||
Human   458 MSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPL 522

  Fly   539 TYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPG----------KTFGSKFGLAMQPTAN 593
            |.....:|.         ||.||..|  .||.::...||          .:...:..:.:||:.:
Human   523 TMGNYVFPK---------WGQGVGWL--MALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSED 576

  Fly   594 W-----GPLQTQ-----KFEAYI 606
            .     ||.|.|     ..||||
Human   577 IVRPENGPEQPQAGSSTSKEAYI 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	166/477 (35%)
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	195/606 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		6/21 (29%)
		PDZ-binding	597..599		1/1 (100%)