DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8850 and si:ch211-132b12.2

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001038688.1	Gene:	si:ch211-132b12.2 / 571877	ZFINID:	ZDB-GENE-050420-178	Length:	582	Species:	Danio rerio

Alignment Length:	574	Identity:	191/574 - (33%)
Similarity:	314/574 - (54%)	Gaps:	25/574 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQF 120
            :|..|....||:.:...:.:|||||||||::..:|||||||:||::.::..|.|::.||..:||:
Zfish    10 ERGNWGSKTEFILAVAGIVIGLGNVWRFPYLCYKNGGGAFLVPYLVFVVTCGVPLFLLETAMGQY 74

  Fly   121 SSRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG-K 183
            :..|.|..:. :.|:..||.|........:..||..|:|..:.||..|||..|||..|...|. .
Zfish    75 TQEGGITCWHRLCPLAEGIGYAGQLIVLYSCMYYIIILAWALFYLAFSFSSQLPWASCDNIWNTD 139

  Fly   184 SCVATGATAANDSS--IVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTI 246
            :||.......|.|:  ::...||...|:...||.....::.  :|..:|:::|||:..|:|....
Zfish   140 ACVNLAENKLNLSTPMLLNSTSSVTEFWQHRVLALSGGIEK--VGKINWEILLCLIVMWIICYFC 202

  Fly   247 LSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMF 311
            :.||::|:||..||.|.||||:::|||||.:|||||.||:|::|.|:.::|.:|.||..|..|:|
Zfish   203 VWKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWMEAGAQIF 267

  Fly   312 FSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVV 376
            ||.|:...:|.:..|:|.:|.|.::..:.:..::|.||::||..:|.:||.:| :.....|.:|.
Zfish   268 FSYALGTASLTVLGSYNKYNYNCYRSSLWLCLLNSSTSVIAGFAVFSVLGFMA-QKQGLPIEEVA 331

  Fly   377 KGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHL-----P 436
            :.|.|||||:||:|:|...: |||:|..||.|:::||:.:........:..|.|.|..:     .
Zfish   332 ESGPGLAFIAYPQAVAMMPF-PQLWAACFFIMIILLGLDTQFVAMEVFMTSVIDLFPTVLRKAGR 395

  Fly   437 HWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDI 500
            ..:..:...:..|...||.:|.||.:|..|.|:|.|:...|: |.:.|.||:||::|.:::...|
Zfish   396 REIFLLLFCLFCFFGQLVMVTEGGMYVFQLFDYYACSGACLLFLCVFESLAMGWVFGAEKMFGII 460

  Fly   501 EFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTY-RGVQYPPVYYMAGWIIWGLGVLQL 564
            |.|.|.:.::::.:||..:.|.:.....|..|..|:|||: |...||...|:.||::....:|.:
Zfish   461 EDMTNSRPNYWFMLCWKYLTPIVSLASFVCSLVKYKPLTFNRWYVYPDWAYVLGWLLALSSILLV 525

  Fly   565 PFWALVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQKFEAYIIHRKREADFKSP 618
            |.|||       |:.|..|..:..:.:....|.....|...|.:::.|   |:|
Zfish   526 PGWAL-------GRMFAGKGSIKQRWSHLCSPDTNPHFACKIQNKRHE---KTP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	165/483 (34%)
si:ch211-132b12.2	NP_001038688.1	SLC6sbd-TauT-like	11..550	CDD:271387	185/549 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820