Protein Alignment CG8850 and slc6a8

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001314797.1
• Gene: slc6a8 / 567544
• ZFINID: ZDB-GENE-071024-2
• Length: 652
• Species: Danio rerio
• Alignment Length: 596
• Identity: 211/596 - (35%)
• Similarity: 330/596 - (55%)
• Gaps: 34/596 - (5%)

  Fly    24 HPGSNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIAL 88
            ||..|..::....||....::. .|.:.|...:|:.|:|.::|:.||:..:||||||||||::..
Zfish    32 HPSVNGTLNGGPMSAATGAISA-VEKKREGYPERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCY 95

  Fly    89 ENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYY 153
            :||||.||||||:.:.|.|.|:::||:.:|||...|.|..:::||:.:|:.|..:.......|||
Zfish    96 KNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKAGSINVWNIAPLFKGLGYASMVIVFFCNTYY 160

  Fly   154 ACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCV-------ATGATAANDS-------SIVQGVS 203
            ..::|....|.:.||:..|||:.|...|. ::|:       ....|..|.:       .:..|.|
Zfish   161 IMVLAWGFYYFIKSFNATLPWSTCDNPWNTENCIEIFRQGDCKNGTIGNSTFGNLTCEELANGRS 225

  Fly   204 SAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVI 268
            ....|:...||...:.||:.  |..:|:|:|||||.||::...:.||::|:||..||.|.||||:
Zfish   226 PIIEFWENKVLNISDGLDEP--GAVNWELMLCLLAVWVMVYFCVWKGVKSTGKIVYFTATFPYVV 288

  Fly   269 MIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKN 333
            :|:||:|.||||||:.||:|::||.||:|....||..|.||:|||.||..|.|....|:|.||.:
Zfish   289 LIILLVRGVTLPGAYDGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNND 353

  Fly   334 VHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLP 398
            .:||..::..|:|.||..||.::|.|||.:|.|... |||:|.:.|.|||||:||:|::.....|
Zfish   354 CYKDAFVLALINSGTSFFAGFVVFSILGFMASEQGV-DISKVAESGPGLAFIAYPKAVSMMPVAP 417

  Fly   399 QLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF--THLPHWLLAVSASIIGFLCGLV---YMTP 458
             ::|.|||.|||:||:.|........|..:.|.|  .:...:...::.:|...||.::   .:|.
Zfish   418 -VWAALFFIMLLLLGLDSQFVGVEGFVTGILDLFPGKYYMRYQREIAVAICCLLCFIIDLSMVTQ 481

  Fly   459 GGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPG 522
            ||.:|..|.|:|..:.:.|: .|..|.:.|.|:||..|...||..|:..:...:.:.||:|:.|.
Zfish   482 GGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPFPWMKWCWSIITPC 546

  Fly   523 LMFLVLVYMLFSYEPLTYRGVQ-YPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGK--TFGSKF 584
            :...:.::.|.:|:||||..|. ||....:.||.:....:|.:|   :..:|:..|.  ||..::
Zfish   547 VCMGIFLFHLLNYKPLTYNNVYVYPWWGEVIGWCLALSSMLCIP---VSLVYKLSGAKGTFKERW 608

  Fly   585 GLAMQPTANWG 595
            ....:|.  ||
Zfish   609 ENLTKPV--WG 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	183/494 (37%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	204/563 (36%)