DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8850 and slc6a8

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	596	Identity:	211/596 - (35%)
Similarity:	330/596 - (55%)	Gaps:	34/596 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HPGSNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIAL 88
            ||..|..::....||....::. .|.:.|...:|:.|:|.::|:.||:..:||||||||||::..
Zfish    32 HPSVNGTLNGGPMSAATGAISA-VEKKREGYPERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCY 95

  Fly    89 ENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYY 153
            :||||.||||||:.:.|.|.|:::||:.:|||...|.|..:::||:.:|:.|..:.......|||
Zfish    96 KNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKAGSINVWNIAPLFKGLGYASMVIVFFCNTYY 160

  Fly   154 ACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCV-------ATGATAANDS-------SIVQGVS 203
            ..::|....|.:.||:..|||:.|...|. ::|:       ....|..|.:       .:..|.|
Zfish   161 IMVLAWGFYYFIKSFNATLPWSTCDNPWNTENCIEIFRQGDCKNGTIGNSTFGNLTCEELANGRS 225

  Fly   204 SAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVI 268
            ....|:...||...:.||:.  |..:|:|:|||||.||::...:.||::|:||..||.|.||||:
Zfish   226 PIIEFWENKVLNISDGLDEP--GAVNWELMLCLLAVWVMVYFCVWKGVKSTGKIVYFTATFPYVV 288

  Fly   269 MIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKN 333
            :|:||:|.||||||:.||:|::||.||:|....||..|.||:|||.||..|.|....|:|.||.:
Zfish   289 LIILLVRGVTLPGAYDGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNND 353

  Fly   334 VHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLP 398
            .:||..::..|:|.||..||.::|.|||.:|.|... |||:|.:.|.|||||:||:|::.....|
Zfish   354 CYKDAFVLALINSGTSFFAGFVVFSILGFMASEQGV-DISKVAESGPGLAFIAYPKAVSMMPVAP 417

  Fly   399 QLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF--THLPHWLLAVSASIIGFLCGLV---YMTP 458
             ::|.|||.|||:||:.|........|..:.|.|  .:...:...::.:|...||.::   .:|.
Zfish   418 -VWAALFFIMLLLLGLDSQFVGVEGFVTGILDLFPGKYYMRYQREIAVAICCLLCFIIDLSMVTQ 481

  Fly   459 GGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPG 522
            ||.:|..|.|:|..:.:.|: .|..|.:.|.|:||..|...||..|:..:...:.:.||:|:.|.
Zfish   482 GGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPFPWMKWCWSIITPC 546

  Fly   523 LMFLVLVYMLFSYEPLTYRGVQ-YPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGK--TFGSKF 584
            :...:.::.|.:|:||||..|. ||....:.||.:....:|.:|   :..:|:..|.  ||..::
Zfish   547 VCMGIFLFHLLNYKPLTYNNVYVYPWWGEVIGWCLALSSMLCIP---VSLVYKLSGAKGTFKERW 608

  Fly   585 GLAMQPTANWG 595
            ....:|.  ||
Zfish   609 ENLTKPV--WG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	183/494 (37%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	204/563 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820