Protein Alignment CG8850 and slc6a2

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_694138.3
• Gene: slc6a2 / 565776
• ZFINID: ZDB-GENE-110408-4
• Length: 625
• Species: Danio rerio
• Alignment Length: 565
• Identity: 212/565 - (37%)
• Similarity: 312/565 - (55%)
• Gaps: 29/565 - (5%)

  Fly    37 SAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVI 101
            ||.|||:            :|:.|.:.::||.|.|..:|.|.||||||::..:|||||||||||:
Zfish    56 SASGEEI------------ERETWGKKMDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYVL 108

  Fly   102 VLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVA 166
            .|.:.|.|::|:|:.:||::..|....:.:.|:.:|:.|..:........||..|:|.::.||.|
Zfish   109 FLFIAGMPLFYMELALGQYNREGAATLWKICPVFKGVGYTVIVIALYVGFYYNVIIAWSLYYLYA 173

  Fly   167 SFSEVLPWTYCLVEWGK-SCV----ATGATAANDSSIV--QGVSSAELFFTQTVLREPESLDDNG 224
            |.:..|||.:|...|.. :|.    ..|....|.:|..  :...:|| |:.:.||...||.....
Zfish   174 SLTSELPWLHCNNPWNSPNCTEPKDINGTVLGNGTSYAKYKNTPAAE-FYERGVLHSHESKGIGD 237

  Fly   225 LGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYF 289
            ||.|.|:|.:||:....|:...|.||::||||..|..|..||::::|||||.:|||||..||..:
Zfish   238 LGLPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITATMPYIVLLVLLIRGITLPGAMNGIRAY 302

  Fly   290 LKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGC 354
            |.....:|.||.||..|.||:||||...||.|:.::|:|.||.|.::|.|:.:||:.:||..:|.
Zfish   303 LHIDLKKLNNPQVWIDAATQIFFSLGAGFGVLIAFSSYNKFNNNCYRDAILTSTINCVTSFFSGF 367

  Fly   355 IIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLP--QLFAVLFFFMLLVLGIGSN 417
            .||.:||.:| |.:..:|..|...||||.|:.|||||:.   ||  ..||::||.|||.|||.|:
Zfish   368 AIFSVLGYMA-EQHKVNIKDVATEGAGLVFVIYPEAIST---LPGATFFAIVFFIMLLTLGIDSS 428

  Fly   418 IGMASAVVNVVKDRFTHLP-HWLLAVSASIIG-FLCGLVYMTPGGQFVLNLVDFYGCTFIALVLA 480
            :|...||:..:.|.|..|. :..|...|:::| ||..|:.:|.||.:||.|:|.|......|...
Zfish   429 MGGMEAVLTGLSDDFKILKRNRKLFTFATVVGTFLMALLCVTNGGIYVLTLLDKYAAGTSILFGV 493

  Fly   481 IAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQY 545
            :.|.:.|.|.|||.|...|||.|:..|...|||:||..|:|..:.||::..:.:...|||....:
Zfish   494 LFEAIGVSWFYGVDRFSEDIERMMGFKPGIYWRLCWKFVSPAFLLLVVIASIVTSGRLTYDEYVF 558

  Fly   546 PPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQP 590
            |....|.||.|....:|.:||:|:...:..| .:|..:....:.|
Zfish   559 PYWADMLGWSIALSSMLFVPFYAIYKFFSVP-SSFKERLAYCVTP 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	191/484 (39%)
slc6a2	XP_694138.3	SLC5-6-like_sbd	64..623	CDD:444915	207/545 (38%)