DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and slc6a15

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001232001.1	Gene:	slc6a15 / 565315	ZFINID:	ZDB-GENE-050420-93	Length:	741	Species:	Danio rerio

Alignment Length:	709	Identity:	198/709 - (27%)
Similarity:	320/709 - (45%)	Gaps:	153/709 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVL 103
            ||.|     |.|.|...:|..|...::::.:.:..|||||||||||::..:|||||:|:||:|:|
Zfish    55 EGSE-----EEEEEEEEERPAWGSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILL 114

  Fly   104 LLIGRPVYYLEVIIGQFSSRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVAS 167
            ||||.|:::||:.:||...||.|..:: ::|.:.||.:...........||..|:..::.|...|
Zfish   115 LLIGIPLFFLELAVGQRIRRGSIGVWNYISPHLGGIGFASCLVCFFVALYYNVIIGWSLFYFSQS 179

  Fly   168 FSEVLPWTYCLVEWGKS-------CVATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGL 225
            |.:.|||..|.:...|:       |..:.||.              .::.:..|...:|:.:.|
Zfish   180 FQQPLPWHECPLVKNKTNTYIEPECEKSSATT--------------YYWYRVALDISDSISEGG- 229

  Fly   226 GTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFL 290
            |. :|.:.|||||.|.::...:.|||:||||..||.:|||||::|..|.||..|.|:..||::..
Zfish   230 GL-NWRMTLCLLAAWTMVCLAMIKGIQSSGKVMYFSSLFPYVVLICFLARAFLLKGSVDGIIHMF 293

  Fly   291 KPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCI 355
            .|:...:|.|.||..|.||:||:|.:.||.::.::|:|..:.|.|.|.::::.|:..||:||..:
Zfish   294 TPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLV 358

  Fly   356 IFGILGNLA-------FETNTKDI------------------------------SQVVKG----- 378
            :|.:||..|       .|.|||.|                              :.:::|
Zfish   359 VFAVLGFKANIMNAKCVEMNTKKIIGFLGKEINPGLIPHHINFSQVSPEDYQQMTNIIQGVMEND 423

  Fly   379 --------------------GAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASA 423
                                |.|||||::.||:..|...| .::|:||.||:.||:||..|....
Zfish   424 YPRLGLDNCDIKEELNKAVQGTGLAFIAFTEAMTHFPASP-FWSVMFFLMLVNLGLGSMFGTIQG 487

  Fly   424 VVNVVKDRFTHLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVG 488
            ::..:.|.|.....: |.|...::.|..||.::...|.:.:.:.|.|..|...|::.:.|.:||.
Zfish   488 ILTPIVDTFKVRKEY-LTVGCCVLAFFIGLTFVQRSGNYFVAMFDDYSATLPLLIVVLLENIAVA 551

  Fly   489 WIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLV------------YMLFSYEPLTYR 541
            |:||..:...|::.||......|:...|..|.|.|:..:|.            |..::.:....:
Zfish   552 WVYGTDKFFEDLKDMLGFTPYRYYYYMWKFVTPVLLLGLLAASVIQLGLAPPSYSAWNQQLAKEQ 616

  Fly   542 GVQYPPVYYMAGWIIWGLGV---------LQLP----FWALVTIYQQPG--KTFGSKFGLAMQPT 591
            .:.|||         |||.|         |.:|    ...|..|.::.|  .|...|.|..::.|
Zfish   617 SLSYPP---------WGLAVCISLVVTAILPVPVVFILRCLNIIDEKTGGLSTVSYKKGRIIKDT 672

  Fly   592 ANWGPLQTQKFEAYIIHRKREADFKSP-----------------------RGGYLFDNI 627
            | ....:..:.:|.:::.|..::..||                       ..|||..||
Zfish   673 A-CRTREDDEDDASLLNAKTPSEAPSPMPANYRKQSGPASAADAKLNGSCSTGYLMPNI 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	165/555 (30%)
slc6a15	NP_001232001.1	SLC5-6-like_sbd	68..646	CDD:294310	175/604 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010