DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8850 and si:ch211-132b12.6

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001038523.1	Gene:	si:ch211-132b12.6 / 564583	ZFINID:	ZDB-GENE-050420-179	Length:	577	Species:	Danio rerio

Alignment Length:	557	Identity:	198/557 - (35%)
Similarity:	314/557 - (56%)	Gaps:	26/557 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVI 116
            |...:|..|.:..|||.:.....||||||||||::...||||.|||||::.::..|.|::.||..
Zfish     6 EEIEERGFWGKKAEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGLPLFLLETA 70

  Fly   117 IGQFSSRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVE 180
            :|||:..|.|..:. :.|:.:|:.|....:...:..||..|:|..:.|||:|||..|||..|...
Zfish    71 MGQFTHEGGITCWHRLCPLAQGVGYAGQLTVLYSCMYYTIILAWALFYLVSSFSSQLPWVSCNNI 135

  Fly   181 WG-KSCV--ATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVI 242
            |. .:||  |.|....|.:::....|:|..|:.:.||.....::|  :|..:|:::|||:|.|:|
Zfish   136 WNTDNCVNLAAGNLTFNRTTLANSTSAATEFWERRVLSLSGGIED--IGKINWEILLCLIAMWII 198

  Fly   243 IGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAI 307
            ....:.||::|:||..||.|.||||:::|||||.:|||||.||:|::|.|:.::|.:|.||..|.
Zfish   199 CYFCIWKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWMEAG 263

  Fly   308 TQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDI 372
            ||:|||.::|.|.|:...|:|.::.|.::|...:..::|.||.:||..:|.:||.:| ......:
Zfish   264 TQVFFSYSVCSGILISLGSYNQYSNNCYRDSFWLCLLNSGTSFVAGFAVFSVLGFMA-HVQGVPV 327

  Fly   373 SQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHL-- 435
            .:|.:.|.|||||:||:|:|...: |||:||.||.|:::||:.|.......|:..|.|.|..:
Zfish   328 EEVAESGPGLAFIAYPQAMAMMPF-PQLWAVCFFIMIILLGLDSQFVGIECVITSVMDLFPEVLR 391

  Fly   436 ---PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKRI 496
               ...|..:...:..|...|:.:|.||.:|..|.|.|.|....|: |::.|.||:||::|.:::
Zfish   392 RAGRRELFVLLLCLTCFFGQLIMVTEGGMYVFQLFDNYACNGACLLFLSVFESLAIGWLFGAEKM 456

  Fly   497 CSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTY-RGVQYPPVYYMAGWIIWGLG 560
            ...||.|...:.::::.:||..:.|.:..:..||.:..|.|||: |...||...|..||::....
Zfish   457 FDIIEDMTESRPNYWFMLCWKYLTPLVSLMSFVYSMVRYTPLTFNRWYVYPDWAYALGWLLALSS 521

  Fly   561 VLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPL 597
            :|.:|.|||       |:.:..|..|..:    ||.|
Zfish   522 ILLVPGWAL-------GQMWAGKGTLKQR----WGHL 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	175/483 (36%)
si:ch211-132b12.6	NP_001038523.1	SLC6sbd-TauT-like	11..550	CDD:271387	197/552 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920