Protein Alignment CG8850 and SLC6A15

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_877499.1
• Gene: SLC6A15 / 55117
• HGNCID: 13621
• Length: 730
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 203/719 - (28%)
• Similarity: 336/719 - (46%)
• Gaps: 126/719 - (17%)

  Fly     1 MDDDAEYQKLRRNMQGAQGSREGHPGSNDGISTVIYSAEG-EELTINCEAESESSGQRDQWSRGV 64
            :|||.        .:..:........::|...|.....:| ||...:.|..||...:|..|:..:
Human    12 LDDDV--------TESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDERPAWNSKL 68

  Fly    65 EFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF 129
            :::.:.:..|||||||||||::..:|||||:|:||:|:|::||.|:::||:.:||...||.|..:
Human    69 QYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVW 133

  Fly   130 D-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYC-LVEWGKSCVATGATA 192
            : ::|.:.||.:...........||..|:..::.|...||.:.|||..| ||   |:...|....
Human   134 NYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLV---KNASHTFVEP 195

  Fly   193 ANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKA 257
            ..:.|     |:...::.:..|....|:.::| |. :|.:.:||||.||::...:.|||:||||.
Human   196 ECEQS-----SATTYYWYREALNISSSISESG-GL-NWKMTICLLAAWVMVCLAMIKGIQSSGKI 253

  Fly   258 SYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLV 322
            .||.:|||||::|..||||..|.|:..||.:...|:...:|.|.||..|.||:||:|.:.||.::
Human   254 IYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVI 318

  Fly   323 MYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTK----------------- 370
            .::|:|..:.|.|.|.::::.|:..||:||..::|.:||..|...|.|
Human   319 AFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGN 383

  Fly   371 ------------------------DISQVVK----------------------GGAGLAFISYPE 389
                                    ||.|.||                      .|.|||||::.|
Human   384 ISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTE 448

  Fly   390 AIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHLPHWLLAVSASIIGFLCGLV 454
            |:..|...| .::|:||.||:.||:||..|....:|..:.|.| .:...:|.|...::.|..||:
Human   449 AMTHFPASP-FWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF-KVRKEILTVICCLLAFCIGLI 511

  Fly   455 YMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIV 519
            ::...|.:.:.:.|.|..|...|::.|.|.:||.::||:.:...|::.||....|.|:...|..:
Human   512 FVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 576

  Fly   520 APGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWI------------IWGLGV-LQLPFWALVT 571
            :|.::..:|:..:.:      .|:. ||.|  ..||            .|||.| :.|..:|::.
Human   577 SPLMLLSLLIASVVN------MGLS-PPGY--NAWIEDKASEEFLSYPTWGLVVCVSLVVFAILP 632

  Fly   572 IYQQPGKTFGSKFGLAMQPTANWG------------PLQTQKFEAYIIHRKREADFKSPRGGYLF 624
            :   |......:|.|....:.|..            |:..:..:..:||.|..::..||..|
Human   633 V---PVVFIVRRFNLIDDSSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFG--- 691

  Fly   625 DNIF 628
            .||:
Human   692 KNIY 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	166/538 (31%)
SLC6A15	NP_877499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..60		6/18 (33%)
		SLC6sbd_SBAT1	61..640	CDD:212091	180/602 (30%)