Protein Alignment CG8850 and SLC6A20

DIOPT Version :9

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001372612.1
• Gene: SLC6A20 / 54716
• HGNCID: 30927
• Length: 603
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 194/624 - (31%)
• Similarity: 307/624 - (49%)
• Gaps: 134/624 - (21%)

  Fly    57 RDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFS 121
            |..|:..::|:|:||:.:||||||||||::....|||:||:||:|:|::.|.|:.|||:.:||..
Human     5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRM 69

  Fly   122 SRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVE----- 180
            .:|.|.|: .::|.:.|:....|..:...:.||..|.|....||..||.:.|||:.|.:.
Human    70 RQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGNHTG 134

  Fly   181 WGKSCVATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGT 245
            :.:.|              :..||.:.|:.:..|....||.:|| |. .|:..||||..|:::..
Human   135 YDEEC--------------EKASSTQYFWYRKTLNISPSLQENG-GV-QWEPALCLLLAWLVVYL 183

  Fly   246 ILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWS-----------QLLN 299
            .:.:|..|:||..||.|..||.::|:.|||.:||.||..|::|...|:.|           ||.|
Human   184 CILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKGSSALSLLAFQIEQLAN 248

  Fly   300 PHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLA 364
            |..|..|.||:||||.:.||:|:.:||:|:.:.|..|..||::.|:|.|||.|..:.|.|.|..|
Human   249 PKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKA 313

  Fly   365 ---FE----------TNTKDIS---------QVVKG----------------------------- 378
               :|          |||.|:.         :.|||
Human   314 TFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTA 378

  Fly   379 --GAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDR---FTHLPHW 438
              |.|||||.|.|||...: :.||::||:|||||:|||||.:|..:|::..:.|.   .:|||..
Human   379 VQGTGLAFIVYTEAIKNME-VSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKE 442

  Fly   439 LLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFM 503
            .::....::....|:|:....|.:..::.:.|..|...|::.:.|.:||.::||::|..||::.|
Human   443 AISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAM 507

  Fly   504 LNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWA 568
            .....|:||::.||.|:|     :|:..||              |:|::.:|:  .|.|:...|
Human   508 TGRAVSWYWKVMWAGVSP-----LLIVSLF--------------VFYLSDYIL--TGTLKYQAW- 550

  Fly   569 LVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQKFEAYII 607
                                  .|:.|.|.|:.:.||.:
Human   551 ----------------------DASQGQLVTKDYPAYAL 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	179/546 (33%)
SLC6A20	NP_001372612.1	SLC6sbd_SIT1	2..588	CDD:271401	194/624 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810