DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a8

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_059044.1	Gene:	Slc6a8 / 50690	RGDID:	619711	Length:	635	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	219/633 - (34%)
Similarity:	328/633 - (51%)	Gaps:	79/633 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IYSAEGEE----LTINCEAESESSGQ----------------RDQWSRGVEFLFSCIALSVGLGN 79
            |||..|:|    |.::....:.|.|.                |:.|:|.::|:.||:..:|||||
  Rat    10 IYSVSGDEKKGPLIVSGPDGAPSKGDGPAGLGAPSSRLAVPPRETWTRQMDFIMSCVGFAVGLGN 74

  Fly    80 VWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVY 144
            |||||::..:||||.||||||::.|:.|.|:::||:.:|||...|.|..:::.|:.:|:.|..:.
  Rat    75 VWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMV 139

  Fly   145 STALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCV-------ATGATAAN------- 194
            ......|||..::|....|||.||:..|||..|...|. ..||       ...|:.||
  Rat   140 IVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLA 204

  Fly   195 --DSSIVQGVSSAELFFTQTVLREPESLDDNGLGTP---SWDLVLCLLATWVIIGTILSKGIRSS 254
              .|.:::       |:...|||.     ..||..|   :|::.|||||.||::...:.||::|:
  Rat   205 DRRSPVIE-------FWENKVLRL-----STGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKST 257

  Fly   255 GKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFG 319
            ||..||.|.||||:::|||:|.|.||||..||:|:|||.||:|.:|.||..|.||:|||.||..|
  Rat   258 GKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLG 322

  Fly   320 TLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAF 384
            .|....|:|.||.|.:||.||:..|:|.||..||.::|.|||.:|.|... .||:|.:.|.||||
  Rat   323 ALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGV-HISKVAESGPGLAF 386

  Fly   385 ISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSN-IGMASAVVNVVKDRFTHLP-----HWLLAVS 443
            |:||.|:......| |:|.|||||||:||:.|. :|:...:..::    ..||     .:...:|
  Rat   387 IAYPRAVTLMPVAP-LWAALFFFMLLLLGLDSQFVGVEGFITGLL----DLLPASYYFRFQREIS 446

  Fly   444 ASIIGFLC---GLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFML 504
            .::...||   .|..:|.||.:|..|.|:|..:...|: .|..|.:.|.|:||..|...||..|:
  Rat   447 VALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMI 511

  Fly   505 NVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMA-GWIIWGLGVLQLPFWA 568
            ..:...:.:.||:...|.:...:.::.:..|:||.|......|.:..| ||......:|.:|...
  Rat   512 GYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYKPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHL 576

  Fly   569 LVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQKFEAYIIHRKREADFK 616
            |..:.:..| |...::....||.  ||       ..::.:|.::||.:
  Rat   577 LGCLLRAKG-TMAERWQHLTQPI--WG-------LHHLEYRAQDADVR 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	190/503 (38%)
Slc6a8	NP_059044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		8/36 (22%)
Slc6a8	NP_059044.1	SLC6sbd_CT1	52..621	CDD:271397	211/591 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920