DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a12

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_059031.1	Gene:	Slc6a12 / 50676	RGDID:	620255	Length:	628	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	212/573 - (36%)
Similarity:	321/573 - (56%)	Gaps:	37/573 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DGISTVIY-SAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGG 92
            ||...|.: ..|||.:.   :.:.:....|.||:..:||:.|.....:|||||||||::..:|||
  Rat    24 DGCPVVSWVPEEGEMMD---QKDKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGG 85

  Fly    93 GAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACI 156
            |||.|||.|.....|.||::|||.:||:||:|.:.|: .:.|:::||....|...:....||..|
  Rat    86 GAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIII 150

  Fly   157 MALTIRYLVASFSEVLPWTYCLVEWG-KSCV------ATGATAANDSSIVQGVSSAELFFTQTVL 214
            :|..:.||.:||:..||||.|...|. :.||      :|.|.:.:::.    .|....|:.:.||
  Rat   151 LAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENF----TSPVMEFWERRVL 211

  Fly   215 REPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTL 279
            .....:.|  ||:..|:|.||||..|:|....:.||::|:||..||.|.|||:::|:||||.|||
  Rat   212 GITSGIHD--LGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTL 274

  Fly   280 PGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTI 344
            |||:||||::|||...:|.:|.||..|.||:|||.|||.|.|....|:|.::.|.::|.|.:..:
  Rat   275 PGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFL 339

  Fly   345 DSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFML 409
            :|.||.:||.::|.|||.:|.|... .||:|.:.|.|||||::|:|:.... |.||::.|||.||
  Rat   340 NSATSFVAGFVVFSILGFMAQEQGV-PISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFLML 402

  Fly   410 LVLGIGSNIGMASAVVNVVKDRFTHLPHW--------LLAVSASIIGFLCGLVYMTPGGQFVLNL 466
            |.||:.|.......:|....|.|   |..        ||.::.:|:.:|.||:.:|.||.::..|
  Rat   403 LFLGLDSQFVCMECLVTASMDMF---PQQLRKRGRRELLILAVAIVCYLMGLLLVTEGGMYIFQL 464

  Fly   467 VDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVY 530
            .|:|..:.|.|: |::.|::.:||:||..|...::|.|:..:.....:|.|..:.|||......:
  Rat   465 FDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFF 529

  Fly   531 MLFSYEPLTYRGVQ-YPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGS 582
            .|..|.||.|..|. ||...|..||::....:..:|.:.::|:.    ||.||
  Rat   530 SLSKYTPLKYNNVYIYPSWGYSIGWLLAFSSMACVPLFIIITLL----KTQGS 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	188/490 (38%)
Slc6a12	NP_059031.1	SLC5-6-like_sbd	49..589	CDD:294310	206/545 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820