DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and slc6a9

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005163551.1	Gene:	slc6a9 / 494490	ZFINID:	ZDB-GENE-050105-3	Length:	653	Species:	Danio rerio

Alignment Length:	588	Identity:	201/588 - (34%)
Similarity:	323/588 - (54%)	Gaps:	48/588 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVI 116
            :.:.:|..|...:||:.:.:..:||||||||||::...||||||:.||.|:|:..|.|:::||:.
Zfish    26 DENSRRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFLELS 90

  Fly   117 IGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEW 181
            .|||:|.||:..:.::|:.:|:.||.:..:.....||..::.:...|...|.:.:||||||...|
Zfish    91 FGQFTSLGCLGVWKVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTNLLPWTYCNNPW 155

  Fly   182 G----KSCVAT---GATAANDSSIVQGV----------SSAELFFTQTVLREPESLDDNGLGTPS 229
            .    ...|:|   .||.||.|::|.||          |.:|.::...||...:.:  ...|...
Zfish   156 NTPDCSGVVSTHRANATFANMSAVVSGVTEIVNRTKRTSPSEEYWRNYVLNISDGI--GNFGEVR 218

  Fly   230 WDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQW 294
            ..::.||..:|.::...|.:|::||||..||.|.||||::.:|.||.:||.||..||.|:|.|||
Zfish   219 LPILGCLAVSWFVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFIRGITLDGAISGIKYYLTPQW 283

  Fly   295 SQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGI 359
            .::|:..||..|.:|:|:||...:|.|:..||:|.|:.|..:|.|||:..:..||:.||.:||.|
Zfish   284 QKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCFRDSIIISVTNCGTSVYAGFVIFSI 348

  Fly   360 LGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAV 424
            ||.:|..... |:|:|...|.||||::||||:......| |:::||||||::||:|:...:...:
Zfish   349 LGFMAHHLGV-DVSEVADHGPGLAFVAYPEALTLLPISP-LWSLLFFFMLILLGLGTQFCLLETL 411

  Fly   425 VNVVKDRFTHLPHWLL------AVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAE 483
            |..|.|...  ..|::      .:..:|||||.|:...|..|.:.|.|:|.|..:|..::::...
Zfish   412 VTAVVDEIG--TDWIIKNKTYVTLGVAIIGFLLGVPLTTQAGIYWLLLMDNYAASFSLVIISCIM 474

  Fly   484 LLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPV 548
            .:.:.::||.|....|:|.||......::||||..|:|.::..:|::.:..|:|:||....||
Zfish   475 CICIMYVYGHKNYFKDVEMMLGFPPPIFFRICWRYVSPFIITFILIFTVIQYKPITYNDYVYP-- 537

  Fly   549 YYMAGW-IIWGL-----GVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQKFEAYII 607
                || ::.|.     .|:.:|.:||..|....|.||..:...:::|..:|||...:
Zfish   538 ----GWSLVIGFAMALSSVICIPIYALFKIAMSEGSTFLERLKNSVKPDPDWGPALQE------- 591

  Fly   608 HRK 610
            |||
Zfish   592 HRK 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	176/496 (35%)
slc6a9	XP_005163551.1	SLC6sbd_GlyT1	15..598	CDD:212067	201/588 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820