Protein Alignment CG8850 and slc6a5

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001009557.1
• Gene: slc6a5 / 494450
• ZFINID: ZDB-GENE-050105-2
• Length: 786
• Species: Danio rerio
• Alignment Length: 638
• Identity: 220/638 - (34%)
• Similarity: 337/638 - (52%)
• Gaps: 65/638 - (10%)

  Fly    16 GAQGSREGHPGSNDGIST----VIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVG 76
            |..|:....||:..|..|    .::..:.::     :...|:.. |..||..::|:.|.:..:||
Zfish   138 GTDGNTSVLPGTVTGPPTDDTGRLFQDDDDD-----DGGDENKA-RGNWSNKLDFILSMVGYAVG 196

  Fly    77 LGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYG 141
            ||||||||::|.:||||||||||:|:|.|.|.|::.|||.:|||:|:|.:..:...|.::|....
Zfish   197 LGNVWRFPYLAFQNGGGAFLIPYLIMLGLAGIPIFLLEVSLGQFASQGPVSVWKAIPALQGCGIA 261

  Fly   142 QVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG------------KSCV-------- 186
            .:..:.|...||..||..|:.||.||..|.|||..|..||.            .:|:
Zfish   262 MLIISVLIAIYYNIIMCWTLYYLFASLKETLPWATCKNEWNTVECKDKDMLLLDTCILRDRNITS 326

  Fly   187 ---ATGATAANDSSIVQG---------------VSSAELFFTQTVLREPESLDDNGLGTPSWDLV 233
               .|...:||    |.|               ||.:|.:|...||...:.::..  |...|.|.
Zfish   327 IKNTTFCLSAN----VVGNLSKLLNVTVDNKTYVSPSEEYFKYNVLHISKGIEYP--GDIRWPLA 385

  Fly   234 LCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLL 298
            .||...|:|:...|:|||:||||..||.|.||||::::||||.||||||..||:||:.|:|.:|.
Zfish   386 ACLFLAWLIVYASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLN 450

  Fly   299 NPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNL 363
            :..||..|.||:||||:..:|.|:..:|:|.|:.|.::|.:|:|..:|.|||.||.:||.::|.:
Zfish   451 DAKVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFM 515

  Fly   364 AFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVV 428
            |.|... .|..|...|.|:||:.||||:.:....| .:|::||.|||.||:.:.......:|..|
Zfish   516 AHELKV-PIESVADEGPGIAFVVYPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSV 578

  Fly   429 KDRF-----THLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVG 488
            .|.|     .|.|.:.|....|.  |:.|...:|..|.::|.|||.:..::..:::||.||:.:.
Zfish   579 SDEFPKYLRKHKPQFTLVCCLSF--FVLGFPMITESGMYMLQLVDTFAASYSLVIIAIFELVGIS 641

  Fly   489 WIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAG 553
            :|||::|.|.|||.|:..:.:.:||:|||.|.|.::..:|...|:.::.:||....||....:.|
Zfish   642 YIYGLQRFCEDIEMMIGFQPNKFWRVCWAFVTPTILTFILALSLYQWKVMTYEDYTYPNWSMVLG 706

  Fly   554 WIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGP-LQTQKFEAY 605
            |::....|:.:|....:.::..||... .:..|...|..:||| |...:.|.|
Zfish   707 WLMVICSVIWIPIMFAIKMHLAPGSLI-ERLKLVCSPQPDWGPFLMKHRGERY 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	193/516 (37%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:444915	213/593 (36%)