DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and SerT

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	206/555 - (37%)
Similarity:	305/555 - (54%)	Gaps:	33/555 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFS 121
            |:.|.:..|||.:.|..:|.||||||||:|..:|||||||:||.:.|:..|.|::|:|:.:|||.
  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138

  Fly   122 SRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG-KS 184
            ..||:..:. :.|.::|:.|...........||..|:...:.||.|||:..||||.|...|. ::
  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203

  Fly   185 CVATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGL---GTPSWDLVLCLLATWVIIGTI 246
            |:.  .|:.|.:.:  ..|.|:.||.:.||   ||...|||   |.....|.||:...:|::...
  Fly   204 CMQ--VTSENFTEL--ATSPAKEFFERKVL---ESYKGNGLDFMGPVKPTLALCVFGVFVLVYFS 261

  Fly   247 LSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMF 311
            |.||:||:||..:..||.|||::|:||:|.|:||||.:||.|:|.|:|.:|.|..||..|.:|:|
  Fly   262 LWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIF 326

  Fly   312 FSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVV 376
            |||...||||:..:|:|.||.|.::|.:|.::|:.|||.|||.:||.:||.:|:...| .|.:|.
  Fly   327 FSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKT-SIDKVG 390

  Fly   377 KGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHL-----P 436
            ..|.||.||.||||||.... ...::::||.||:.||:.|..|...|::..:.|.:..:     .
  Fly   391 LEGPGLVFIVYPEAIATMSG-SVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRE 454

  Fly   437 HWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIE 501
            .::|.:.|.|  |||.|..||.||..::|.::.||.....|.:...|...|.|.|||.|..||:|
  Fly   455 LFVLLLLAFI--FLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVE 517

  Fly   502 FMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPF 566
            .||..|...:|||||..::|..:..:.::.:..|:.:......||...|..||.:....||.:|.
  Fly   518 QMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPM 582

  Fly   567 WALVTIYQQPGKTFGSKFGL------AMQPTANWG 595
            :.:...:      |.||.|.      :.||..|.|
  Fly   583 YIIYKFF------FASKGGCRQRLQESFQPEDNCG 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	188/483 (39%)
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	203/549 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2944
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800