DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and slc6a22.1

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005166076.1	Gene:	slc6a22.1 / 368923	ZFINID:	ZDB-GENE-030616-629	Length:	584	Species:	Danio rerio

Alignment Length:	571	Identity:	207/571 - (36%)
Similarity:	316/571 - (55%)	Gaps:	25/571 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EAESESSGQ----RDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGR 108
            :|:|..:|.    |.|||..|||:.:.....:|||||||||::..:||||.|.||||:.|...|.
Zfish    17 DAQSNETGLKTQIRGQWSSKVEFILAVAGQIIGLGNVWRFPYLCYKNGGGVFFIPYVVFLFACGI 81

  Fly   109 PVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVL 172
            |::.:|..:||::|:|.:..: .:.|:..|:.||.......::.||..|:|....||.:|||..|
Zfish    82 PLFLMETALGQYTSQGSVTCWRKICPLFEGLGYGSQVVVLYSSAYYIIILAWAFFYLFSSFSGEL 146

  Fly   173 PWTYCLVEW-GKSCVATGAT--AANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVL 234
            ||..|...| .::||.....  |.|.|.:....|..:.|:.:.||....|:  |.||:..|:|.|
Zfish   147 PWASCRNWWNSENCVEFDRMQGAKNLSFMANASSPVKEFWERRVLNITGSV--NELGSVRWELAL 209

  Fly   235 CLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLN 299
            |||..|||....:.||::|:||..||.|.||||:::|||||.:|||||..||.::|.|..::|.:
Zfish   210 CLLLAWVICYFCVWKGVKSTGKVVYFTATFPYVMLMVLLIRGLTLPGAIDGITFYLYPNPARLAD 274

  Fly   300 PHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLA 364
            |.||..|.||:|:|.|:|.|.|....|:|.:|.|.:||.:.:..::|.||.:||..||.:||.:|
Zfish   275 PQVWMDAGTQIFYSYALCIGCLTALGSYNKYNNNCYKDCVYLCLLNSGTSFVAGFAIFSVLGFMA 339

  Fly   365 FETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSN-IGMASAVVNV- 427
            .|... |||.|.:.|.|||||:||.|:|... :.||:::.||.|:::||:.|. :|:.|.:..:
Zfish   340 LEQGV-DISVVAESGPGLAFIAYPRAVAMMP-MAQLWSICFFLMIILLGLDSEFVGLESLMTAIT 402

  Fly   428 -VKDRFTHLPH----WLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVL-AIAELLA 486
             :...|....|    :||.:  .|..||.||:.:|.||.:|..|.|:|.|:.:.|:| |||:.:.
Zfish   403 DMNPNFFLQGHRRKLFLLVI--CIACFLIGLLMVTEGGLYVFQLFDYYSCSGMTLLLFAIAQSIC 465

  Fly   487 VGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGV-QYPPVYY 550
            :||.||..|:..:|..|:........:.||..:.|.:.....::.|..:.||.:... :||...|
Zfish   466 IGWFYGADRLYENIADMIGYHPLTLMKYCWKYITPIVCIGTFIFSLVKFTPLKFNNTYEYPWWGY 530

  Fly   551 MAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQK 601
            .|||.......|.:|.|.:..|...|| |...:..:...|.::. ||.:::
Zfish   531 AAGWWFTLSSTLLVPIWMIYAILVTPG-TLKQRLRVLCTPASDL-PLTSER 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	184/485 (38%)
slc6a22.1	XP_005166076.1	SLC6sbd-TauT-like	30..569	CDD:271387	201/545 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820