Protein Alignment CG8850 and SLC6A18

DIOPT Version :9

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_872438.2
• Gene: SLC6A18 / 348932
• HGNCID: 26441
• Length: 628
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 184/604 - (30%)
• Similarity: 301/604 - (49%)
• Gaps: 87/604 - (14%)

  Fly    49 AESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYL 113
            |..:...:|.:|....::|.||...:|||||:||||::....|||||||||||.|:..|.|::::
Human    10 AACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHV 74

  Fly   114 EVIIGQFSSRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYC 177
            |:.|||...:|.:..:. ::|.:.|:..|.|..:.|.:.||..|:|..:.||:.||...|||:.|
Human    75 ELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSC 139

  Fly   178 LVEWGKSCVATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVI 242
            ..:..:    ||....     .||.|:...|:.:..|.....::|:  |:..|.|::||.|:|.:
Human   140 PPDLNR----TGFVEE-----CQGSSAVSYFWYRQTLNITADINDS--GSIQWWLLICLAASWAV 193

  Fly   243 IGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAI 307
            :...:.:||.::||..||.|||||:::.:.|||.:|||||.:|::|...|....|.||.||..|.
Human   194 VYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAA 258

  Fly   308 TQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLA-------- 364
            ||:||||::.||..:.:||:|....:..||.::|..::.:||:.|...:|.:||..|
Human   259 TQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCL 323

  Fly   365 ----------FE--------------------TNTKDISQV-------------VKGGAGLAFIS 386
                      |:                    |..|.::|:             ...|.||||:.
Human   324 DRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVV 388

  Fly   387 YPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHLPHWL----LAVSASII 447
            :.|........| ::|:|||.||..||:.:..|...||:..:.| ...||.|:    |.....::
Human   389 FTETDLHMPGAP-VWAMLFFGMLFTLGLSTMFGTVEAVITPLLD-VGVLPRWVPKEALTGLVCLV 451

  Fly   448 GFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYW 512
            .||....:....|.:.|.:.|.:..:...|:||..|::.|.::||:||.|.||.:|...:.|.||
Human   452 CFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYW 516

  Fly   513 RICWAIVAPGLMFLVLVY-MLFSYEPLTYRGVQYPPVYYM---------AGW------IIWGLGV 561
            |:.|.:|:|.|:.:.:.| :|..::||.|:.  :.|.|.:         .||      ::..|.|
Human   517 RLTWRVVSPLLLTIFVAYIILLFWKPLRYKA--WNPKYELFPSRQEKLYPGWARAACVLLSLLPV 579

  Fly   562 LQLPFWALVTIYQQPGKTF 580
            |.:|..||..:..:..:|:
Human   580 LWVPVAALAQLLTRRRRTW 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	167/530 (32%)
SLC6A18	NP_872438.2	SLC6sbd_B0AT3	17..591	CDD:212086	182/588 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..628

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810