DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and CG13793

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_609136.2	Gene:	CG13793 / 34047	FlyBaseID:	FBgn0031935	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	147/613 - (23%)
Similarity:	260/613 - (42%)	Gaps:	91/613 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RDQWSRGVEFLFSCIALSVGL----GNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVII 117
            |..|.:..:::|:|..|::.|    .:.|.|     .|.|...::||::.:::...|:..:...:
  Fly    12 RGNWEKPTDYIFACFGLALKLDIFVASFWFF-----FNTGIFGMVPYLMYMVIYLVPIMVIHSYM 71

  Fly   118 GQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYC--LVE 180
            |||||.|.|.||.::|:.:|:.|..::.|.....||....|:.:.:::.||...|||: |  ...
  Fly    72 GQFSSSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPWS-CEGFKS 135

  Fly   181 WGKSCVA----TGATAANDSSIVQGVSSAELFFTQTVLREPESL----------DDNGLG--TPS 229
            |....:|    ..||.|.:   |...:..:.:|..|.:..|..|          :|:.|.  ..|
  Fly   136 WQNDTIAKWSICNATIAEE---VAKETENDTYFYITNIHVPSVLYFKSHFESFQNDSELNDYEIS 197

  Fly   230 WDLVLCLLATWVIIGTILSKGIRSS--GKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKP 292
            |.|.......|..|..|..|....:  ||...::.:....:::|..:|.:.||||..|:..::.|
  Fly   198 WHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAHLGLKNYMTP 262

  Fly   293 QWSQLLNPHVWYAAITQMFFSLAI-----CFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILA 352
            ...:       :...|...|.:|:     .:|:::..:|||.|..|:.....||:.......|:.
  Fly   263 SIEE-------FVVGTSSTFIMALQAFGAGWGSVITLSSFNGFKTNIMSYSWIISFGQIFIYIMF 320

  Fly   353 GCIIFGI------LGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLV 411
            |.:.|.:      |....|||      ||:  ...:.|:|...|::...: |.|:..:::.|||:
  Fly   321 GMVSFMLEHYFLGLPKPLFET------QVI--NHWVLFLSSASALSSLGW-PNLWTFIYYTMLLM 376

  Fly   412 LGIGSNIGMASAVVNVVK---DRFTHLPHWLLAVSASIIGFL--CGLVYMTPGGQF---VLNLVD 468
            ..:   |.:.:.:..:::   |.|..|......|:..:||.|  |.|.:.|..|..   :|::..
  Fly   377 AAL---IVITTQIFTILQSLFDEFEQLRAKKQEVTLGLIGGLAVCSLYFCTNHGVLYFAILSIDA 438

  Fly   469 FYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYML- 532
            .:..|.:.|:|    ||.|.|:||..|...||:|||....:.:.......|||..:.:.||..:
  Fly   439 IFSQTLLHLLL----LLVVLWVYGRDRFQKDIKFMLGQPFASWKVFILRFVAPPTLVICLVLEIK 499

  Fly   533 FSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPL 597
            ...|..:|..    .|.:....|:.||.:|.:|.:....|:|:|| :....|     ...:|.|:
  Fly   500 MCLEEHSYSS----SVLHFMAIILVGLPILAIPAYGFYYIHQRPG-SISELF-----RATDWYPV 554

  Fly   598 QTQKFEAYIIHRKREADFKSPRGGYLFD 625
            :.:..:.|     .|...||.....|||
  Fly   555 EMEYRQQY-----GELVQKSEMTHQLFD 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	124/516 (24%)
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	123/510 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840