Protein Alignment CG8850 and SLC6A19

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001003841.1
• Gene: SLC6A19 / 340024
• HGNCID: 27960
• Length: 634
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 193/632 - (30%)
• Similarity: 308/632 - (48%)
• Gaps: 107/632 - (16%)

  Fly    28 NDGISTVIYS-AEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENG 91
            |.|:...|.| ||.|.:      |.|.:..|.:|....:::.:|:...||||||||||::...:|
Human     8 NPGLDARIPSLAELETI------EQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHG 66

  Fly    92 GGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYAC 155
            ||||:||::|:|:|.|.|:.|||..|||...||.:..: .:.|.::|:....:.::.:...||..
Human    67 GGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNT 131

  Fly   156 IMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGV---SSAELFFTQTVLREP 217
            |::..:.||..||.|.|||:.|.:.            .|.:..|...   |..:.|:.:..|...
Human   132 IISWIMWYLFNSFQEPLPWSDCPLN------------ENQTGYVDECARSSPVDYFWYRETLNIS 184

  Fly   218 ESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGA 282
            .|:.|:  |:..|.::|||...|.::.....:||.::|||.|..:..|||::.:.|||.:||.||
Human   185 TSISDS--GSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGA 247

  Fly   283 WQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSL 347
            ..|||:...|..::|..|..|..|..|:|||.::.||.|:.::|:|..:.|..||.:|::.|:..
Human   248 TNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGF 312

  Fly   348 TSILAGCIIFGILGNLA-------FETN------------------------------------- 368
            ||:....:::.::|..|       |.||
Human   313 TSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQ 377

  Fly   369 ----TKDI----SQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVV 425
                |.||    |:.|: |.|||||.:.|||.|....| |::||||.||..||:.|..|....||
Human   378 LVFQTCDINAFLSEAVE-GTGLAFIVFTEAITKMPLSP-LWSVLFFIMLFCLGLSSMFGNMEGVV 440

  Fly   426 NVVKDRFTHLPHWLLAVSASII---GFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAV 487
            ..::|.....|.|...|...:|   .||.|.::....||:.|:|:|.|..:...|::|..|:.:|
Human   441 VPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSV 505

  Fly   488 GWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSY-----EPLTY------- 540
            .::|||.|...|||||:..|.:.:|::.|.:|:|   .|:|:..||.:     :.|||
Human   506 VYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSP---LLMLIIFLFFFVVEVSQELTYSIWDPGY 567

  Fly   541 ------RGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIY----QQPG 577
                  :.:.||...|:...|:.|:..|.:|.:|:..:.    |:||
Human   568 EEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPG 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	167/532 (31%)
SLC6A19	NP_001003841.1	SLC5-6-like_sbd	32..612	CDD:444915	181/598 (30%)