DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a14

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	630	Identity:	225/630 - (35%)
Similarity:	341/630 - (54%)	Gaps:	66/630 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EELTINCE----AESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVI 101
            :::|.:.|    .|::.:.:|..||:..::|.|.:..:||||||||||::...||||||||||.|
  Rat    22 QKVTASSENFHVGENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAI 86

  Fly   102 VLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVA 166
            :|.|.|.|:::||..:|||:|.|.:..:.:.|:.:|:....|..:...|.||..|:|.::.||.|
  Rat    87 MLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFA 151

  Fly   167 SFSEVLPWTYCLVEWG-KSC----VATGA----------------------TAANDSSIVQ-GVS 203
            ||..||||..|...|. .:|    :.||.                      |..|.|.:.: |..
  Rat   152 SFQSVLPWANCSSSWADDNCSRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPGQL 216

  Fly   204 SAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVI 268
            .:|.::.:..||....:|:.|:..  |.|.||||..|:|:|..|.|||:||||..||.||||||:
  Rat   217 PSEQYWDKVTLRRSSGMDETGVIV--WYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVV 279

  Fly   269 MIVLLIRAVTLPGAWQGIVYFLKPQ--WSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFN 331
            :::||||..||.||.:||.|::..|  :::|....||..|.||:|:||::.:|.||..:|:|.||
  Rat   280 LLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFN 344

  Fly   332 KNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKY 396
            .|.:.|.||:...:.|||:.||..||.|||::| ..:.|::|||||.|..||||:||||:|:...
  Rat   345 NNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMA-HISGKEVSQVVKSGFDLAFIAYPEALAQLPG 408

  Fly   397 LPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF------THLPHWLLAVSASIIGFLCGLVY 455
            .| .:::|||||||.||:.|.......:...::|.|      ..:|   :.:...:|.||.|||.
  Rat   409 GP-FWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKAMKRMRVP---ITLGCCLILFLLGLVC 469

  Fly   456 MTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFY---WRICWA 517
            :|..|.:.::|:|.:...:..|:.||.|:..:.||||..|...|||.|:..|...:   ||.||.
  Rat   470 VTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACWF 534

  Fly   518 IVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGW------IIWGLGVLQLPFWALVTIYQQP 576
            ::.|.|:..:||:.|..:....|..:.||......||      |||      :|..|::.|.:..
  Rat   535 VITPILLSAILVWSLVKFHRPNYADIPYPDWGVALGWCMIIFCIIW------IPIMAIIKIVRAE 593

  Fly   577 GKTFGSKFGLAMQPTANWGP-LQTQKFEAY--IIHRKREADFKSP 618
            |... .:.....:|.:|||| |:..:.|.|  :....:|.|.:.|
  Rat   594 GNIL-QRIIKCCRPASNWGPYLEKHRGERYKDMAEPAKETDHEIP 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	197/512 (38%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	222/610 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920