DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a4

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_037166.2	Gene:	Slc6a4 / 25553	RGDID:	3714	Length:	630	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	202/568 - (35%)
Similarity:	321/568 - (56%)	Gaps:	27/568 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NDGISTVIYSAEGEELTINCEAESES------SGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFI 86
            ::|.|.|..::.|:|.:.:..|.:.:      .|:|:.|.:.::||.|.|..:|.|||:||||:|
  Rat    44 SNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYI 108

  Fly    87 ALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALAT 150
            ..:|||||||:||.|:.:..|.|::|:|:.:||:...|||..: .:.||.:||.|..........
  Rat   109 CYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIA 173

  Fly   151 TYYACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGVSSAELFFTQTVLR 215
            :||..|:|..:.||::|.::.||||.|...|............|.:..:...|.||.|:.:.||:
  Rat   174 SYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQ 238

  Fly   216 EPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLP 280
            ..:|.....|||.||.|.||::..:.:|...:.||:::|||..:..|.|||:::.|||:|..|||
  Rat   239 IHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLP 303

  Fly   281 GAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTID 345
            |||:|:|::|||.|.:||...||..|..|:||||...||.|:.:||:|.||.|.::|.::.:.::
  Rat   304 GAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVN 368

  Fly   346 SLTSILAGCIIFGILGNLAFETNTKDISQVVK-GGAGLAFISYPEAIAKFKYLP--QLFAVLFFF 407
            .:||.::|.:||.:||.:| |...:|:|:|.| .|..|.||:|.||||.   :|  ..||::||.
  Rat   369 CMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSLLFITYAEAIAN---MPASTFFAIIFFL 429

  Fly   408 MLLVLGIGSNIGMASAVVNVVKDRFTHL----PHW--LLAVSASIIGFLCGLVYMTPGGQFVLNL 466
            ||:.||:.|.......|:..|.|.|.|:    ..|  |:.|...::|   .|:.:|.||.:|:.|
  Rat   430 MLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLG---SLLTLTSGGAYVVTL 491

  Fly   467 VDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYM 531
            ::.|......|.:|:.|.:||.|.||:.:.|||::.||.....::|||||..::|  :||:.:..
  Rat   492 LEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISP--LFLLFIIC 554

  Fly   532 LFSYEPLTYRGVQ--YPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPG 577
            .|...|...|..|  ||....:.|:.|....|:.:|.:.:..:...||
  Rat   555 SFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPG 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	182/483 (38%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..60		5/15 (33%)
		5HT_transport_N	24..64	CDD:397524	5/19 (26%)
		SLC6sbd_SERT	79..615	CDD:271399	195/533 (37%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920