Protein Alignment CG8850 and Slc6a3

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 569
• Identity: 195/569 - (34%)
• Similarity: 305/569 - (53%)
• Gaps: 17/569 - (2%)

  Fly    34 VIYSAEGEELT----INCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGA 94
            ::....|.:||    ||.......:.:|:.||:.::||.|.|..:|.|.||||||::..:|||||
  Rat    33 LVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGA 97

  Fly    95 FLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMAL 159
            ||:||::.:::.|.|::|:|:.:|||:..|....:.:.|:::|:.:..:..:.....:|..|:|.
  Rat    98 FLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAW 162

  Fly   160 TIRYLVASFSEVLPWTYCLVEWGK-SCVATGATAANDS-----SIVQGVSSAELFFTQTVLREPE 218
            .:.|..:||:..|||.:|...|.. :|  :.|.|:|.|     :...|.:.|..:|.:.||...:
  Rat   163 ALHYFFSSFTMDLPWIHCNNTWNSPNC--SDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQ 225

  Fly   219 SLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAW 283
            |...:.||.|.|.|..||:...|::...|.||:::|||..:..|..|||::..||:|.||||||.
  Rat   226 SRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAM 290

  Fly   284 QGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLT 348
            .||..:|...:.:|....||..|.||:.|||.:.||.|:.::|:|.|..|.::|.||.|:|:|||
  Rat   291 DGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLT 355

  Fly   349 SILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLG 413
            |..:|.::|..||.:|.:.|. .|..|...|.||.||.||||||... |...:|.:||.|||.||
  Rat   356 SFSSGFVVFSFLGYMAQKHNV-PIRDVATDGPGLIFIIYPEAIATLP-LSSAWAAVFFLMLLTLG 418

  Fly   414 IGSNIGMASAVVNVVKDRF--THLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIA 476
            |.|.:|...:|:..:.|.|  .|....|..:...:..||..|..:|.||.:|..|:|.:......
  Rat   419 IDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSI 483

  Fly   477 LVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYR 541
            |...:.|.:.|.|.|||::...||:.|...:.:.|||:||.:|:|..:..|:|..:.::.|..|.
  Rat   484 LFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYG 548

  Fly   542 GVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQP 590
            ...:|......||||....:..:|.:|.......|| :|..|...|:.|
  Rat   549 AYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITP 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	174/481 (36%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	190/542 (35%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		9/29 (31%)