DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a11

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_766478.1	Gene:	Slc6a11 / 243616	MGIID:	95630	Length:	627	Species:	Mus musculus

Alignment Length:	558	Identity:	209/558 - (37%)
Similarity:	315/558 - (56%)	Gaps:	17/558 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYY 112
            ||..::..:|..|:..|||:.|.....:|||||||||::..:|||||||||||:..:..|.||::
Mouse    36 EARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFF 100

  Fly   113 LEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTY 176
            ||..:|||:|.|.|..: .:.|:..||.|......|....||..|:|..|.||...|:..|||..
Mouse   101 LETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWAT 165

  Fly   177 CLVEWG-KSCVA-TGATAANDSSI-VQGVSSAEL-FFTQTVLREPESLDDNGLGTPSWDLVLCLL 237
            |..||. :.||. .....:|.|.: :|..:|..: |:.:.||...:.::.  :|...|:|.||||
Mouse   166 CGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEH--IGNLRWELALCLL 228

  Fly   238 ATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHV 302
            |.|.|....:.||.:|:||..|..|.|||:::::||||.||||||.:||.::|.|..|:|.:|.|
Mouse   229 AAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQV 293

  Fly   303 WYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFET 367
            |..|.||:|||.|||.|.|....|:|::|.|.::|.|::..::|.||.:||..||.:||.:|:|.
Mouse   294 WVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQ 358

  Fly   368 NTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF 432
            .. .|::|.:.|.|||||:||:|:......| |:|.|||.||:.||:.|......::|..|.|.:
Mouse   359 GV-PIAEVAESGPGLAFIAYPKAVTMMPLSP-LWATLFFMMLIFLGLDSQFVCVESLVTAVVDMY 421

  Fly   433 THL-----PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIY 491
            ..:     ...||.::.|||.:..|||.:|.||.::..|.|.|..:.:.|: :||.|.:.:||:|
Mouse   422 PKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVY 486

  Fly   492 GVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGV-QYPPVYYMAGWI 555
            |..|...:||.|:..:.....:.||.:|.||:...:.::.|..|:||.|..| .||...|..||:
Mouse   487 GSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWL 551

  Fly   556 IWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTAN 593
            :....:|.:|.|..:.:::..| |...|......|:|:
Mouse   552 MALSSMLCIPLWIFIKLWKTEG-TLPEKLQKLTVPSAD 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	187/484 (39%)
Slc6a11	NP_766478.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		209/558 (37%)
Slc6a11	NP_766478.1	SLC6sbd_GAT3	44..585	CDD:212077	205/545 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820