Protein Alignment CG8850 and Slc6a1

DIOPT Version :9

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_848818.1
• Gene: Slc6a1 / 232333
• MGIID: 95627
• Length: 599
• Species: Mus musculus
• Alignment Length: 608
• Identity: 197/608 - (32%)
• Similarity: 317/608 - (52%)
• Gaps: 48/608 - (7%)

  Fly    29 DG-ISTVIYSA-----EGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIA 87
            || |||.:..|     :.:.|.:..:.::.....||.|....:||.||:..::|||||||||::.
Mouse    10 DGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLC 74

  Fly    88 LENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTY 152
            .:||||||||||.:.|:..|.|::.||..:||::|.|.:..:.:||:.:|:.......:.....|
Mouse    75 GKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIY 139

  Fly   153 YACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGVSSAELFFTQTVLREP 217
            |..|::..|.||..||:..|||..|...|......:..:..|.:::...|..   |:.:.:.:..
Mouse   140 YIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVE---FWERNMHQMT 201

  Fly   218 ESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGA 282
            :.||..  |...|.|.:.|...||::...:.||:..:||..||.|.:||:::|:|..|.||||||
Mouse   202 DGLDKP--GQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGA 264

  Fly   283 WQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSL 347
            .:||::::.|.:.:|.:..||..|.||:|||..:..|:|:...|:|.|:.||::|.||:..|:|.
Mouse   265 KEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSC 329

  Fly   348 TSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVL 412
            ||:.||.:||.|:|.:|..|. :.|:.|...|.||||::||||:.:....| |:|:|||.|||:|
Mouse   330 TSMFAGFVIFSIVGFMAHVTK-RSIADVAASGPGLAFLAYPEAVTQLPISP-LWAILFFSMLLML 392

  Fly   413 GIGSNIGMASAVVNVVKDRFTHL---PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTF 474
            ||.|........:..:.|.:..|   ...|...:..|:.:|.||..:|.||.:|..|.|:|..:.
Mouse   393 GIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASG 457

  Fly   475 IALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPL 538
            ::|: |...|.:::.|.|||.|...:|:.|:..:...:|::||:...|.::..|.::......||
Mouse   458 MSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPL 522

  Fly   539 TYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPG----------KTFGSKFGLAMQPTAN 593
            |.....:|.         ||.||..|  .||.::...||          .:...:..:.:||:.:
Mouse   523 TMGSYVFPK---------WGQGVGWL--MALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSED 576

  Fly   594 W-----GPLQTQ-----KFEAYI 606
            .     ||.|.|     ..||||
Mouse   577 IVRPENGPEQPQAGSSASKEAYI 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	166/477 (35%)
Slc6a1	NP_848818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/12 (50%)
		SLC6sbd_GAT1	2..599	CDD:212075	195/606 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		6/21 (29%)
		PDZ-binding	597..599		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820