Protein Alignment CG8850 and Slc6a18

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001035782.1
• Gene: Slc6a18 / 22598
• MGIID: 1336892
• Length: 615
• Species: Mus musculus
• Alignment Length: 645
• Identity: 192/645 - (29%)
• Similarity: 307/645 - (47%)
• Gaps: 131/645 - (20%)

  Fly    38 AEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIV 102
            |.|.:..::.|.|      |.:|...:::|.|||..:|||||:||||::...:|||||||||.|.
Mouse     4 ASGMDPLVDIEDE------RPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIA 62

  Fly   103 LLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVA 166
            |:..|.|::|:|:.|||...||.|..: .::|.:.|:..|....:.|.:.||..::...:.:.:.
Mouse    63 LVFEGIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTVLLWVLWFFLN 127

  Fly   167 SFSEVLPWTYCLVEWGKS-----CVATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGLG 226
            ||...|||:.|.::..::     |.::|..             :..::.||:   ..:.|.:..|
Mouse   128 SFQHPLPWSTCPLDLNRTGFVQECQSSGTV-------------SYFWYRQTL---NITSDISNTG 176

  Fly   227 TPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLK 291
            |..|.|.|||:|.|..:...:.:||.|:||..||.|||||:::.:.|||.:|||||.:|::|...
Mouse   177 TIQWKLFLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLIYLFT 241

  Fly   292 PQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCII 356
            |....|.||.||..|.||:||||::.||..:.:||:|....|..||.:||..::|:||:.|...|
Mouse   242 PNMKTLQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALVNSMTSLYASIAI 306

  Fly   357 FGILGNLA------------------FE--------------------TNTKDISQV-------- 375
            |.::|..|                  |:                    |.|..::|:
Mouse   307 FSVMGFKASNDYGRCLDRNILSLINEFDLPELSISRDEYPSVLMYLNATQTARVAQLPLKTCHLE 371

  Fly   376 -----VKGGAGLAFISYPEAIAKFKYLP--QLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFT 433
                 ...|.|||||.:.||:.   ::|  .:::||||.||..||:.|..|....|:..:.| ..
Mouse   372 DFLDKSASGPGLAFIVFTEAVL---HMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLLD-MG 432

  Fly   434 HLPHWL-LAVSASIIGFLC---GLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVK 494
            .||..: ..|...:|.|.|   .:.:....|.:.|.:.|.:..:...::.|..|::.|..|||:|
Mouse   433 ILPKGIPKEVMTGVICFACFLSAICFTLQSGGYWLEIFDSFAASLNLIIFAFMEVVGVIHIYGMK 497

  Fly   495 RICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVY---------- 549
            |.|.|||:|...:...||::.|.:|:|.|:|.:.:    ||..|.   :|.||.|
Mouse   498 RFCDDIEWMTGRRPGLYWQVTWRVVSPMLLFGIFL----SYIVLL---IQTPPSYKAWNPQYEHF 555

  Fly   550 ------YMAGWI------------IW--GLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQ 589
                  :..||:            :|  |:.:.|     |::.|:|..|....:.||.:|
Mouse   556 PSREEKFYPGWVQVTCVLLSFLPSLWVPGVALAQ-----LLSQYKQRWKATHLESGLKLQ 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	168/536 (31%)
Slc6a18	NP_001035782.1	SLC6sbd_B0AT3	16..591	CDD:212086	182/612 (30%)