DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	555	Identity:	205/555 - (36%)
Similarity:	305/555 - (54%)	Gaps:	42/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ESESSG---QRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVY 111
            |.|:.|   ||::||..::|:.|.....||||||||||::..:||||||||||.|.|...|.||:
Mouse    41 EDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVF 105

  Fly   112 YLEVIIGQFSSRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWT 175
            :|||||||::|.|.|..:: :.|:..||.|..:...:|...||..|:|....||..||.:.|||.
Mouse   106 FLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWA 170

  Fly   176 YCLVEWGKSCVATGATAANDSSIVQGVSSAEL------FFTQTVLREPESLDDNGLGTPSWDLVL 234
            :|...|............|:|..| .:|:|..      |:.:.||.....:|:.  |:..|||.|
Mouse   171 HCNHSWNTPQCMEDTLRRNESHWV-SLSTANFTSPVIEFWERNVLSLSSGIDNP--GSLKWDLAL 232

  Fly   235 CLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLN 299
            |||..|::....:.||:||:||..||.|.||:.:::|||:|.:|||||.:||.::|.|..|:|.:
Mouse   233 CLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGD 297

  Fly   300 PHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLA 364
            |.||..|.||:|||.|||.|.:....|:|.:..|.::|.:::..::|.||.::|..||.|||.:|
Mouse   298 PQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMA 362

  Fly   365 FETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVK 429
            .|... ||:.|.:.|.|||||:||:|:.... ||..:::|||.|||:||:.|........:..:.
Mouse   363 QEQGV-DIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFFIMLLLLGLDSQFVEVEGQITSLV 425

  Fly   430 DRFTHLPHWL---------LAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAEL 484
            |.:   |.:|         :|:..| |.:|.||..:|.||.:|..|.|:|..:.:.|: :|..|.
Mouse   426 DLY---PSFLRKGYRREIFIAILCS-ISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFEC 486

  Fly   485 LAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGV-QYPPV 548
            ..:.||||...:...||.|:..:...:.:..||::.|.|.....|:.|..|.||||..| :||
Mouse   487 FVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVYRYP-- 549

  Fly   549 YYMAGWII---WGL---GVLQLPFWALVTIYQQPG 577
                .|.|   |||   .:|.:|...::.:.:..|
Mouse   550 ----DWAIGLGWGLALSSMLCIPLVIVILLCRTEG 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	183/490 (37%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	201/545 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910