DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8850 and Slc6a4

DIOPT Version :9

Sequence 1:NP_725122.2 Gene:CG8850 / 36331 FlyBaseID:FBgn0033708 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_034614.2 Gene:Slc6a4 / 15567 MGIID:96285 Length:630 Species:Mus musculus


Alignment Length:572 Identity:206/572 - (36%)
Similarity:322/572 - (56%) Gaps:28/572 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PGS-NDGISTVIYSAEGEELTINCEAESES------SGQRDQWSRGVEFLFSCIALSVGLGNVWR 82
            ||. ::|.|.|..::.|:|...:..|.:.:      .|:|:.|.:.::||.|.|..:|.|||:||
Mouse    40 PGQISNGYSAVPSTSAGDEAPHSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWR 104

  Fly    83 FPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYST 146
            ||:|..:|||||||:||.|:.:..|.|::|:|:.:||:...|||..: .:.||.:||.|......
Mouse   105 FPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIA 169

  Fly   147 ALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGVSSAELFFTQ 211
            ....:||..|:|..:.||::||::.||||.|...|............|.:..:...|.||.|:.:
Mouse   170 FYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLR 234

  Fly   212 TVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRA 276
            .||:..:|.....|||.||.|.||::..:.||...:.||:::|||..:..|.|||:::.|||:|.
Mouse   235 HVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRG 299

  Fly   277 VTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIII 341
            .||||||:|:|::|||.|.:||...||..|..|:||||...||.|:.:||:|.||.|.::|.::.
Mouse   300 ATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVT 364

  Fly   342 TTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVK-GGAGLAFISYPEAIAKFKYLP--QLFAV 403
            :.::.:||.::|.:||.:||.:| |...:|:|:|.| .|..|.||:|.||||.   :|  ..||:
Mouse   365 SVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSLLFITYAEAIAN---MPASTFFAI 425

  Fly   404 LFFFMLLVLGIGSNIGMASAVVNVVKDRFTHL----PHW--LLAVSASIIGFLCGLVYMTPGGQF 462
            :||.||:.||:.|.......|:..|.|.|.|:    ..|  |:.|...|:|   .|:.:|.||.:
Mouse   426 IFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILG---SLLTLTSGGAY 487

  Fly   463 VLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLV 527
            |:.|::.|......|.:|:.|.:.|.|.||:.:.|||::.||.....::|||||..::|  :||:
Mouse   488 VVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISP--LFLL 550

  Fly   528 LVYMLFSYEPLTYRGVQ--YPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPG 577
            .:...|...|...|..|  ||....:.|:.|....|:.:|.:.:..:...||
Mouse   551 FIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPG 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8850NP_725122.2 SLC6sbd 58..532 CDD:271359 184/483 (38%)
Slc6a4NP_034614.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 7/22 (32%)
5HT_transport_N 24..64 CDD:281488 7/23 (30%)
SLC6sbd_SERT 79..615 CDD:271399 197/533 (37%)
Interaction with RAB4A. /evidence=ECO:0000250 616..624
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0733
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2944
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.770

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