Protein Alignment CG8850 and Slc6a4

DIOPT Version :10

• Sequence 1: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Alignment Length: 572
• Identity: 206/572 - (36%)
• Similarity: 322/572 - (56%)
• Gaps: 28/572 - (4%)

  Fly    25 PGS-NDGISTVIYSAEGEELTINCEAESES------SGQRDQWSRGVEFLFSCIALSVGLGNVWR 82
            ||. ::|.|.|..::.|:|...:..|.:.:      .|:|:.|.:.::||.|.|..:|.|||:||
Mouse    40 PGQISNGYSAVPSTSAGDEAPHSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWR 104

  Fly    83 FPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYST 146
            ||:|..:|||||||:||.|:.:..|.|::|:|:.:||:...|||..: .:.||.:||.|......
Mouse   105 FPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIA 169

  Fly   147 ALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGVSSAELFFTQ 211
            ....:||..|:|..:.||::||::.||||.|...|............|.:..:...|.||.|:.:
Mouse   170 FYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLR 234

  Fly   212 TVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRA 276
            .||:..:|.....|||.||.|.||::..:.||...:.||:::|||..:..|.|||:::.|||:|.
Mouse   235 HVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRG 299

  Fly   277 VTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIII 341
            .||||||:|:|::|||.|.:||...||..|..|:||||...||.|:.:||:|.||.|.::|.::.
Mouse   300 ATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVT 364

  Fly   342 TTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVK-GGAGLAFISYPEAIAKFKYLP--QLFAV 403
            :.::.:||.::|.:||.:||.:| |...:|:|:|.| .|..|.||:|.||||.   :|  ..||:
Mouse   365 SVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSLLFITYAEAIAN---MPASTFFAI 425

  Fly   404 LFFFMLLVLGIGSNIGMASAVVNVVKDRFTHL----PHW--LLAVSASIIGFLCGLVYMTPGGQF 462
            :||.||:.||:.|.......|:..|.|.|.|:    ..|  |:.|...|:|   .|:.:|.||.:
Mouse   426 IFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILG---SLLTLTSGGAY 487

  Fly   463 VLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLV 527
            |:.|::.|......|.:|:.|.:.|.|.||:.:.|||::.||.....::|||||..::|  :||:
Mouse   488 VVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISP--LFLL 550

  Fly   528 LVYMLFSYEPLTYRGVQ--YPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPG 577
            .:...|...|...|..|  ||....:.|:.|....|:.:|.:.:..:...||
Mouse   551 FIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPG 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	184/483 (38%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		7/22 (32%)
		5HT_transport_N	24..64	CDD:397524	7/23 (30%)
		SLC6sbd_SERT	79..615	CDD:271399	197/533 (37%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624