DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a7

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	608	Identity:	227/608 - (37%)
Similarity:	344/608 - (56%)	Gaps:	42/608 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 REGH---PGSNDGISTVIYSAEGE-ELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVW 81
            :|.|   |.:.|.:.|.  |.:|: :|.::..|:      |..|:..::||.|||...|||||||
  Rat     5 QEAHLRKPVTPDLLMTP--SDQGDVDLDVDFAAD------RGNWTGKLDFLLSCIGYCVGLGNVW 61

  Fly    82 RFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYST 146
            |||:.|..|||||||:||.::|.:.|.|:::||:.:|||||.|.:..:.::|:.:|.....:...
  Rat    62 RFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIV 126

  Fly   147 ALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCV-------ATGATAANDSSIVQGVS 203
            .|...||..|:|..:.||.||.:..|||.:|...|. :.|:       ..||...|.||.   ||
  Rat   127 GLVAIYYNMIIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSST---VS 188

  Fly   204 SAELFFTQTVLREPESLDDNGLGTPS---WDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFP 265
            .:|.::::.||....|   .|:|.|.   |:|.||||..|||:...:.||::||||..||.|.||
  Rat   189 PSEEYWSRYVLHIQGS---QGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFP 250

  Fly   266 YVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDF 330
            |:|:::||:|.|||||||:||.::|.||:..||:..||..|..|:|:||.:.||.|:.:||:|.|
  Rat   251 YLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTF 315

  Fly   331 NKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFK 395
            ::|:::|..|:|..:::||||||..||.:||.::.|... .:.||.|.|.||||:.||:|:....
  Rat   316 HQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGV-PVDQVAKAGPGLAFVVYPQAMTMLP 379

  Fly   396 YLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHLPHWLLAVSASIIGFLC------GLV 454
            ..| .::.|||||||.||:.|.......:|..|.|.|   |::|....|...|.:|      ||:
  Rat   380 LSP-FWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEF---PYYLRPKKAVFSGLICVAMYLMGLI 440

  Fly   455 YMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIV 519
            ..|.||.:.|.|:|.|..:|..:|:.|...|||..:||::|.|.||..||..|...|:|.||..:
  Rat   441 LTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFL 505

  Fly   520 APGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKF 584
            :|..:..:|||.:..|:|..|...::|....:.|.::..|..|.:|...||.:.::.|..: .:.
  Rat   506 SPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEGSLW-ERL 569

  Fly   585 GLAMQPTANWGP-LQTQKFEAYI 606
            ..|.:|..:||| |:..:...|:
  Rat   570 QQASRPAIDWGPSLEENRTGMYV 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	199/490 (41%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	214/555 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920