DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a9

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006238687.1	Gene:	Slc6a9 / 116509	RGDID:	621243	Length:	638	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	196/599 - (32%)
Similarity:	327/599 - (54%)	Gaps:	53/599 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFS 121
            |..|...:||:.:.:..:||||||||||::...||||||:.||.|:|:..|.|::::|:..|||:
  Rat    32 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFA 96

  Fly   122 SRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWGKSCV 186
            |:||:..:.::|:.:|:.||.:..:.....||..::.:...|..:|.:.||||.||...|.....
  Rat    97 SQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDC 161

  Fly   187 ATGATAANDSS-----------------IVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVL 234
            |....|:|.::                 .:|..|.:|.::...||:..:.:.|  .|.....|:.
  Rat   162 AGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGD--FGEVRLPLLG 224

  Fly   235 CLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLN 299
            ||..:||::...|.:|::||||..||.|.||||::.:|.:|.|||.||:.||:|:|.|:|.::|.
  Rat   225 CLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILE 289

  Fly   300 PHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLA 364
            ..||..|.:|:|:||...:|.|:..||:|.|:.|.::|.:||:..:..||:.||.:||.|||.:|
  Rat   290 AKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMA 354

  Fly   365 FETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVK 429
            ..... |:|:|...|.||||::||||:......| |:::||||||::||:|:...:...:|..:.
  Rat   355 NHLGV-DVSRVADHGPGLAFVAYPEALTLLPISP-LWSLLFFFMLILLGLGTQFCLLETLVTAIV 417

  Fly   430 DRFTHLPHWLL------AVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVG 488
            |...:  .|:|      .:..::.|||.|:...:..|.:.|.|:|.|..:|..:|::....:::.
  Rat   418 DEVGN--EWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIM 480

  Fly   489 WIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAG 553
            :|||.:....||:.||......:::|||..|:|.::|.:|::.:..|.|:||...|||      |
  Rat   481 YIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYP------G 539

  Fly   554 WIIWGLG-------VLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQKFEAYIIHRK- 610
            |.: .:|       |:.:|.:||..:.:..|.|...:...|.:|:.:|||       |.:.||.
  Rat   540 WAV-AIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGP-------ALLEHRTG 596

  Fly   611 --READFKSPRGGY 622
              ......||..|:
  Rat   597 RYAPTTTPSPEDGF 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	168/496 (34%)
Slc6a9	XP_006238687.1	SLC6sbd_GlyT1	16..599	CDD:212067	193/586 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820