DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and Slc6a5

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006540608.1	Gene:	Slc6a5 / 104245	MGIID:	105090	Length:	831	Species:	Mus musculus

Alignment Length:	630	Identity:	223/630 - (35%)
Similarity:	344/630 - (54%)	Gaps:	53/630 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGG 93
            |||::|:..:.. ..||..:.:.:.:..|..||..::|:.|.:..:||||||||||::|.:||||
Mouse   198 DGIASVLPGSVA-TTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGG 261

  Fly    94 AFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMA 158
            ||||||:::|.|.|.|:::|||.:|||:|:|.:..:...|.::|.....:..:.|...||..|:.
Mouse   262 AFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIIC 326

  Fly   159 LTIRYLVASFSEVLPWTYCLVEWG------------KSCVA------------------TGATAA 193
            .|:.||.|||..||||..|...|.            .|||.                  ...|..
Mouse   327 YTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMV 391

  Fly   194 NDSSIVQG--VSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGK 256
            |.:|....  ||.:|.:|...||:....::..  |...|.|..||...|||:...|:|||:||||
Mouse   392 NFTSQTNKTFVSGSEEYFKYFVLKISAGIEYP--GEIRWPLAFCLFLAWVIVYASLAKGIKSSGK 454

  Fly   257 ASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTL 321
            ..||.|.||||::::||||.||||||..||.||:.|:|.:|.:..||..|.||:||||:..:|.|
Mouse   455 VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGL 519

  Fly   322 VMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFIS 386
            :..:|:|.|:.|.::|.:|:|..:|.|||.||.:||.::|.:|.|... :|..|...|.|:||:.
Mouse   520 ITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVADQGPGIAFVV 583

  Fly   387 YPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF-----THLPHWLLAVSASI 446
            ||||:.:....| .:|::||.|||.||:.:.......:|..:.|.|     ||.|  :..:...|
Mouse   584 YPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKP--VFTLGCCI 645

  Fly   447 IGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFY 511
            ..|:.|...:|.||.::..|||.|..::..:::||.||:.:.::||::|.|.|||.|:..|.:.:
Mouse   646 CFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIF 710

  Fly   512 WRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQP 576
            |::|||.|.|.::..:|.:..:.:||:||...:||....:.||::....|:.:|...::.:|..|
Mouse   711 WKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAP 775

  Fly   577 GKTFGSKFGLAMQPTANWGPLQTQKFEAYIIHR-KREADFKSPRG 620
            |: |..:..|...|..:|||...|       || :|..:...|.|
Mouse   776 GR-FIERLKLVCSPQPDWGPFLAQ-------HRGERYKNMIDPLG 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	191/510 (37%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	217/602 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020