DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8850 and slc6a11b

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_017213744.2	Gene:	slc6a11b / 100150472	ZFINID:	ZDB-GENE-121116-2	Length:	617	Species:	Danio rerio

Alignment Length:	617	Identity:	216/617 - (35%)
Similarity:	323/617 - (52%)	Gaps:	48/617 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 STVIYSAEGEELTINCEAESESS---------GQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIA 87
            |..|.:.:.|| :::.|:.:.|:         .:|.||:..|||:.|.....:|||||||||::.
Zfish     6 SIPIINGKAEE-SMDPESANPSAVRSNDKKVVNERGQWNNKVEFVLSVAGEIIGLGNVWRFPYLC 69

  Fly    88 LENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATT 151
            .:||||||.:||||..:..|.||::||..:|||:|.|.|..: .:.|:..||.|......|....
Zfish    70 YKNGGGAFFVPYVIFFVCCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNV 134

  Fly   152 YYACIMALTIRYLVASFSEVLPWTYCLVEWG-KSCVATGATAANDSSIVQ-----GVSSAELFFT 210
            ||..|:|..|.||...|:..|||..|...|. ::||     ..|:.||..     ..|....|:.
Zfish   135 YYVVILAWAIFYLFNCFTTELPWASCGHYWNTENCV-----DFNNESIANFTNPYSTSPVMEFWE 194

  Fly   211 QTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIR 275
            :.||:....:::  :|...|:|.|||...|||....:.||.:|:||..|..|.|||.::::||:|
Zfish   195 RRVLKISSGIEE--VGGLRWELALCLAIAWVICYFCIWKGPKSTGKVVYVTATFPYFMLLILLLR 257

  Fly   276 AVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVII 340
            .:|||||..||.::|.|..|:|.:|.||..|.||:|||.|||.|.|....|:|.:|.|.::|.::
Zfish   258 GITLPGAANGIKFYLYPDISRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNSYNNNCYRDCLM 322

  Fly   341 ITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLF 405
            :..::|.||.:||..||.:||.:|:|.|. .|..|.:.|.|||||:||:|:....:.| |:|.||
Zfish   323 LCCLNSGTSFVAGFAIFSVLGFMAYEQNV-PIEAVAESGPGLAFIAYPKAVTMMPWAP-LWAALF 385

  Fly   406 FFMLLVLGIGSNIGMASAVVNVVKDRF-----THLPHWLLAVSASIIGFLCGLVYMTPGGQFVLN 465
            |.||:.||:.|......::|..:.|.:     ......||.:..||..|..||:.:|.||.:|..
Zfish   386 FMMLIFLGLDSQFVCVESLVTAIVDMYPKTFRVGYRRELLILGMSIASFFLGLIMLTEGGMYVFQ 450

  Fly   466 LVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLV 529
            |.|.|..:.:.|: :||.|.:.:||:||..|...:||.|:..|..|:.:.||....||:...:.:
Zfish   451 LFDSYAASGMCLLFVAIFESICIGWVYGSDRFYLNIEDMIGYKPIFFIKWCWKFFTPGICTGIFL 515

  Fly   530 YMLFSYEPLTYRGV-QYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTAN 593
            :.|..|:||.|..| .||...|..||::....::.:|...|..|::..| ||..:......|:|:
Zfish   516 FFLIKYKPLKYNNVYTYPDWGYGIGWMMAMSSMVCIPLGILFQIWKTKG-TFRERIKKLTTPSAD 579

  Fly   594 W---------GPLQTQKFEAYIIHRKREADFK 616
            .         ||......:|     |..||.|
Zfish   580 LRMRGHVASRGPCAINDADA-----KMRADGK 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	183/486 (38%)
slc6a11b	XP_017213744.2	SLC5-6-like_sbd	38..576	CDD:320982	201/547 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920