DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8850 and si:ch211-132b12.1

DIOPT Version :9

Sequence 1:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001076533.1	Gene:	si:ch211-132b12.1 / 100034467	ZFINID:	ZDB-GENE-050420-315	Length:	586	Species:	Danio rerio

Alignment Length:	544	Identity:	190/544 - (34%)
Similarity:	312/544 - (57%)	Gaps:	20/544 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 INCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRP 109
            ||.|.|     :|..|...:|||.:.....||||||||||::..:.|||||||||::.::..|.|
Zfish     4 INGEIE-----ERGYWGSKMEFLLAVAGNVVGLGNVWRFPYLCYKYGGGAFLIPYLVFVVTCGVP 63

  Fly   110 VYYLEVIIGQFSSRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLP 173
            ::.||:.:||::.:|.:..:. :.|:..||.||.......:..||..|:|..:.||:.||...||
Zfish    64 LFLLEMAMGQYTQQGGVTCWHRLCPLAEGIGYGGQLILLYSCMYYIVILAWALFYLIFSFKSQLP 128

  Fly   174 WTYCLVEWG-KSCV--ATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLC 235
            |..|...|. ..|:  .|.....|.:|::....:|..|:.:.||.....::|  :|..:|:::||
Zfish   129 WATCDNTWNTDDCINLVTKNLTINRTSLINSTPAATEFWERRVLSLSGGIED--IGKINWEILLC 191

  Fly   236 LLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNP 300
            |:|.|:|....:.||::|:||..||.|.||||:::|||||.:|||||.||:|::|.|:.::|.:|
Zfish   192 LIAMWIICYFCVWKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADP 256

  Fly   301 HVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAF 365
            .||..|.||:.||.::..|::.:.||:|.::.|.::|.:.:..::|:||.:||..:|.:||.:|.
Zfish   257 QVWLEAGTQILFSYSVSVGSITVLASYNKYHNNCYRDCLGLCLLNSVTSFVAGFAVFTVLGFMAQ 321

  Fly   366 ETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKD 430
            |... .|.:|.:.|.|||||:||:|:|...: |||:||.||.|:::||:.:......|||..|.|
Zfish   322 EQGV-PIEEVAESGPGLAFIAYPQAVAMMPF-PQLWAVCFFIMIILLGLDTQFVSMEAVVTSVMD 384

  Fly   431 RFTHL-----PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGW 489
            .|..:     ...:|.:...:..|....:.:|.||.:|..|.|:|.|....|: |::.|.|.:||
Zfish   385 MFPVVLRREGRREILLLFFCLTCFFGQFIMVTEGGMYVFQLFDYYACNGTCLLFLSVFESLTMGW 449

  Fly   490 IYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTY-RGVQYPPVYYMAG 553
            |:|..|:...||.|...:.::.:.:||..:.|.:..:..|..:..|:|||: |...:|...|:.|
Zfish   450 IFGADRLFDIIEDMTKSRPNYIFMLCWKYLTPLVSLVCFVCSMVEYQPLTFNRWYVFPDWAYVLG 514

  Fly   554 WIIWGLGVLQLPFWALVTIYQQPG 577
            |::....::.:|.|||..:..:.|
Zfish   515 WLLALSSIVLVPGWALGRLCSEKG 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	171/483 (35%)
si:ch211-132b12.1	NP_001076533.1	SLC6sbd-TauT-like	11..549	CDD:271387	186/532 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820