Protein Alignment INPP5B and inpp5b

DIOPT Version :10

• Sequence 1: NP_005531.2
• Gene: INPP5B / 3633
• HGNCID: 6077
• Length: 913
• Species: Homo sapiens
• Sequence 2: XP_009290335.3
• Gene: inpp5b / 563543
• ZFINID: ZDB-GENE-110411-228
• Length: 907
• Species: Danio rerio
• Alignment Length: 927
• Identity: 550/927 - (59%)
• Similarity: 686/927 - (74%)
• Gaps: 53/927 - (5%)

Human     1 MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGD 65
            |||||||||||||||.|.|||:.|....|.|.|:|:||||.     .:|||||:|:||||||||:
Zfish     1 MDQSVAIQETLAEGESCTIAVECVSLLNDVRDSKLIGLVRQ-----NKEHALFIYSHRRMAITGE 60

Human    66 DVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARA-- 128
            ||:|.||:|:|.||::.|||...||.::|:|..|::...|..|..:|||||.||:||.||.||
Zfish    61 DVTLGQIIPISYDFSVVEVSSPDELAVVGADTRVRVTFLEEELELKLPFGSHTRLFLSEVNRAWS 125

Human   129 --CPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATI---------GGGGSNF 182
              |..:..  .:|:|.||::||        ...:|..| |....|..|:         ....:|.
Zfish   126 DVCQQYPK--EEPKFDWLTKYR--------KVSKGARS-LRKSIGATTVKMSQMKKAERAHTANS 179

Human   183 DGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEI-TDMVRSSTITVSDKAHILSMQKFGLRDT 246
            ..|:..      |:|:||    ::|| .|.|.|.|: .|::|:|...:|:||.:|.|.:|||||.
Zfish   180 SALKKE------DESARG----DALQ-SQEKVKGEVKDDLIRNSQPVLSNKAQMLGMPQFGLRDN 233

Human   247 IVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAF 311
            ::|..||:.|:.||||:|:.||.||||||||:|||.|..||::....||.|.:||||||||||||
Zfish   234 LIKCELLKNEDAYTYIENYSFFLGTYNVNGQTPKESLSPWLASTASPPDFYLIGFQELDLSKEAF 298

Human   312 FFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGR 376
            .|:|||||.||..||.:|||||||||.|||:||||||||.|||.|||.:||||||||||||:|||
Zfish   299 LFNDTPKEPEWMLAVYKGLHPDAKYALVKLVRLVGIMLLFYVKAEHAPHISEVEAETVGTGVMGR 363

Human   377 MGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDV 441
            |||||.|:|||||||:.|||||||||||.||:||||||:||||.|:||.|.||:||||||..|::
Zfish   364 MGNKGAVSIRFQFHNSDICVVNSHLAAHTEEFERRNQDFKDICRRIQFRQEDPTLPPLTILKHNI 428

Human   442 ILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDT 506
            :||||||||||.:|:|:.||.||.:|||:.|:.|||||.|:..:.||.||||||:.|||||||||
Zfish   429 VLWLGDLNYRISDLEVDHVKDLISKKDFETLHTYDQLKRQMDEEVVFVGFTEGEIDFQPTYKYDT 493

Human   507 GSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKT 571
            |||.||||||||.|||||||||:||:|.||.|||||.|||||||||||:.:||::|||:|.|::|
Zfish   494 GSDQWDTSEKCRVPAWCDRILWRGKSIKQLHYQSHMTLKTSDHKPVSSLLEIGIKVVNEESYKRT 558

Human   572 LEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHN-GQVPCHFEFINKPDEESYC 635
            .|||||.:|::||..|||||||:|||.||:||:||.:..:.|:|| |||||.||||.|.||.:||
Zfish   559 FEEIVRQIDRLENDCIPSVSLSEREFHFQDVKFMQHQARTVTVHNDGQVPCQFEFIQKLDEPAYC 623

Human   636 KQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYL 700
            |.||.|||::|||...:.|:||||:|||:.||.:||:|..::||||||||:||||||:|::|:||
Zfish   624 KPWLTANPAKGFLAQGASVDIDLEVFVNRHTAPELNAGLQQLEDILVLHLERGKDYFISITGSYL 688

Human   701 PSCFGSPIHTLCYMREPILDLPLETISELTL---MPVWTGDDGSQLDSPMEIPKELWMMVDYLYR 762
            ||||||.:..||.:||||.|:|||:|.||::   .||.     ...|.|.|||||:|||||:|:|
Zfish   689 PSCFGSSLSALCLLREPIQDMPLESIRELSVKSNSPVI-----DSADKPQEIPKEIWMMVDHLFR 748

Human   763 NAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCL 827
            .|.:|||||||||||||||.||||||||.:|.|..|||||||||||||::||||||.:|.|..||
Zfish   749 YAKKQEDLFQQPGLRSEFEEIRDCLDTGCLDTLPGSNHSVAEALLLFLDALPEPVIPFSFYQQCL 813

Human   828 ECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQK 892
            :|..:.:..:|:||.||..|||||:||.|||:|||::||.|.||.|::|.||..||||:|   .|
Zfish   814 DCCSDSSHCRQIISMLPQCHKNVFNYLTAFLQELLRHSAYNRLDVNVVAPIFAGLLLRSP---DK 875

Human   893 LDMTEKKKAQEFIHQFL 909
            .|:.||:|.:||...||
Zfish   876 QDINEKRKVKEFFQHFL 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5B	NP_005531.2	INPP5B_PH	1..146	CDD:465268	79/148 (53%)
		INPP5c_INPP5B	265..558	CDD:197327	215/292 (74%)
		RhoGAP_OCRL1	692..912	CDD:239845	131/221 (59%)
inpp5b	XP_009290335.3	INPP5B_PH	1..143	CDD:465268	79/148 (53%)
		INPP5c_INPP5B	253..545	CDD:197327	215/291 (74%)
		PapD-like	574..>648	CDD:373355	46/73 (63%)
		RhoGAP_OCRL1	680..892	CDD:239845	129/219 (59%)