DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cam and EFCAB6

DIOPT Version :9

Sequence 1:	NP_001246276.1	Gene:	Cam / 36329	FlyBaseID:	FBgn0000253	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	XP_011528618.1	Gene:	EFCAB6 / 64800	HGNCID:	24204	Length:	1613	Species:	Homo sapiens

Alignment Length:	161	Identity:	34/161 - (21%)
Similarity:	68/161 - (42%)	Gaps:	29/161 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMM--- 73
            |.::||.|.|...:.|::..||..::.......|..:.||::.::....:||:.:..||:..
Human   100 ELQKAFQLLDTGQNLTVSKSELRRIITDFLMPLTREQFQDVLAQIPLSTSGTVPYLAFLSRFGGI 164

  Fly    74 -----------------ARKMKDTDSE---------EEIREAFRVFDKDGNGFISAAELRHVMTN 112
                             .|.:::.:.:         :.:.:||.:.|.:..|.:...|||.|:..
Human   165 DLYINGIKRGGGNEMNCCRTLRELEIQVGEKVFKNIKTVMKAFELIDVNKTGLVRPQELRRVLET 229

  Fly   113 LGEKLTDEEVDEMIREADIDGDGQVNYEEFV 143
            ...||.|||.::..:..:|..|..|:|..|:
Human   230 FCMKLRDEEYEKFSKHYNIHKDTAVDYNVFL 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cam	NP_001246276.1	PTZ00184	1..149	CDD:185504	34/161 (21%)
EFCAB6	XP_011528618.1	EFh	100..152	CDD:298682	12/51 (24%)
		EF-hand_7	203..261	CDD:290234	18/58 (31%)
		EFh	203..261	CDD:298682	18/58 (31%)
		FRQ1	320..495	CDD:227455
		EFh	434..494	CDD:238008
		FRQ1	989..1135	CDD:227455
		EF-hand_11	1186..1286	CDD:286115
		EFh	1211..1264	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910