DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cam and RCN2

DIOPT Version :9

Sequence 1:	NP_001246276.1	Gene:	Cam / 36329	FlyBaseID:	FBgn0000253	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_001258766.1	Gene:	RCN2 / 5955	HGNCID:	9935	Length:	335	Species:	Homo sapiens

Alignment Length:	176	Identity:	40/176 - (22%)
Similarity:	67/176 - (38%)	Gaps:	44/176 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLT 71
            |||....:......|.|.||.:|..||.:.::...::....|.:....|.|.:.:.|:.:.|:..
Human    60 EEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWDEYNI 124

  Fly    72 MMARKMKDTD--------SEEEIREAFRV----------------------FDK----DGNG--- 99
            .|..::.|.|        .||..|:.|.:                      |:|    .|.|
Human   125 QMYDRVIDFDENTALDDAEEESFRKEFAICKKQSFCFWLLRFNLHLKDKKRFEKANQDSGPGLSL 189

  Fly   100 --FISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFV 143
              ||:......|     :.:|:..:.|.:.|.|.:|||.|:.|||:
Human   190 EEFIAFEHPEEV-----DYMTEFVIQEALEEHDKNGDGFVSLEEFL 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cam	NP_001246276.1	PTZ00184	1..149	CDD:185504	40/176 (23%)
RCN2	NP_001258766.1	EFh_CREC_RCN2	29..314	CDD:320022	40/176 (23%)
		EF-hand motif	29..59	CDD:320022
		EF-hand motif	65..94	CDD:320022	7/28 (25%)
		EF-hand motif	101..130	CDD:320022	6/28 (21%)
		EF-hand motif	171..200	CDD:320022	6/28 (21%)
		EF-hand motif	208..237	CDD:320022	10/23 (43%)
		EF-hand motif	249..278	CDD:320022
		EF-hand motif	285..314	CDD:320022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910