DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cam and PPP3R1

DIOPT Version :9

Sequence 1:	NP_001246276.1	Gene:	Cam / 36329	FlyBaseID:	FBgn0000253	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_000936.1	Gene:	PPP3R1 / 5534	HGNCID:	9317	Length:	170	Species:	Homo sapiens

Alignment Length:	151	Identity:	51/151 - (33%)
Similarity:	85/151 - (56%)	Gaps:	9/151 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTID 65
            |......::|....:.|...|.|..|:::.:|..: :..|.|||.   :|.:|:..|.||||.:|
Human    11 MCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMS-LPELQQNPL---VQRVIDIFDTDGNGEVD 71

  Fly    66 FPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNL-GEKLTDEE----VDEM 125
            |.||:..:::.....|.|:::|.|||::|.|.:|:||..||..|:..: |..|.|.:    ||:.
Human    72 FKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKT 136

  Fly   126 IREADIDGDGQVNYEEFVTMM 146
            |..||.||||::::|||..::
Human   137 IINADKDGDGRISFEEFCAVV 157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cam	NP_001246276.1	PTZ00184	1..149	CDD:185504	51/151 (34%)
PPP3R1	NP_000936.1	FRQ1	13..157	CDD:227455	50/147 (34%)
PPP3R1	NP_000936.1	Calcineurin A binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26794871, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	131..136		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53747
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920