DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cam and PEF1

DIOPT Version :9

Sequence 1:	NP_001246276.1	Gene:	Cam / 36329	FlyBaseID:	FBgn0000253	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_036524.1	Gene:	PEF1 / 553115	HGNCID:	30009	Length:	284	Species:	Homo sapiens

Alignment Length:	176	Identity:	43/176 - (24%)
Similarity:	72/176 - (40%)	Gaps:	52/176 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EAFSLF---DKDGDGTITTKELGTVMRSLGQNPTEAELQD-----MINEVDADGNGTIDFPEFLT 71
            ||:|.|   |.|..|.|:.|||...:    .|...:...|     |||..|...:|.||...|..
Human   118 EAYSWFQSVDSDHSGYISMKELKQAL----VNCNWSSFNDETCLMMINMFDKTKSGRIDVYGFSA 178

  Fly    72 MMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDE---------------- 120
            :.       ...::.:..|:.:|:|.:|.||..||:..::.:|..|:.:
Human   179 LW-------KFIQQWKNLFQQYDRDRSGSISYTELQQALSQMGYNLSPQFTQLLVSRYCPRSANP 236

  Fly   121 --EVD-------------EMIREAD--IDGDGQVNYEEFVTMMTSK 149
              ::|             |..||.|  :.|:.::::|:||||..|:
Human   237 AMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRLSFEDFVTMTASR 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cam	NP_001246276.1	PTZ00184	1..149	CDD:185504	42/174 (24%)
PEF1	NP_036524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111
		9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P. /evidence=ECO:0000305	21..109
		EFh_PEF_peflin	118..283	CDD:320059	43/176 (24%)
		EF-hand motif	118..147	CDD:320059	12/32 (38%)
		EF-hand motif	155..184	CDD:320059	8/35 (23%)
		EF-hand motif	185..215	CDD:320059	8/29 (28%)
		Required for interaction with PDCD6. /evidence=ECO:0000269\|PubMed:11883899	204..284		16/79 (20%)
		EF-hand motif	221..251	CDD:320059	1/29 (3%)
		EF-hand motif	252..283	CDD:320059	11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910