DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cam and EFCAB9

DIOPT Version :9

Sequence 1:	NP_001246276.1	Gene:	Cam / 36329	FlyBaseID:	FBgn0000253	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_001164654.1	Gene:	EFCAB9 / 285588	HGNCID:	34530	Length:	197	Species:	Homo sapiens

Alignment Length:	146	Identity:	32/146 - (21%)
Similarity:	65/146 - (44%)	Gaps:	13/146 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEF 69
            |:...:....|.|.:.|..|..|:........:..: .:..:|::..:.:.:|.:..|.|||.:|
Human    21 LSVRNVKALAEYFHILDVHGKNTLNDVLFYHFLHHV-TDLKKAQINIVFDMLDWNAVGEIDFEKF 84

  Fly    70 LTMMARKMKDTDSEE------EIREAFRVFDKDGNGFISAA--ELRHVMTNLGEKLTDEEVDEMI 126
            ..::...:...:..|      ..|..|.:.|..|:..|.|.  |:...:.|:.:    :|:.::.
Human    85 YMLVCMLLAHQNHLEGQFMYRHSRPVFDLLDLKGDLRIGAKNFEMYRFLFNIQK----QELKDLF 145

  Fly   127 READIDGDGQVNYEEF 142
            |:.||.||.::||:||
Human   146 RDFDITGDNRLNYQEF 161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cam	NP_001246276.1	PTZ00184	1..149	CDD:185504	32/146 (22%)
EFCAB9	NP_001164654.1	EF-hand_7	108..162	CDD:290234	18/58 (31%)
		EFh	110..161	CDD:298682	15/54 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..197
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910