DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cam and Calb1

DIOPT Version :9

Sequence 1:	NP_001246276.1	Gene:	Cam / 36329	FlyBaseID:	FBgn0000253	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_033918.1	Gene:	Calb1 / 12307	MGIID:	88248	Length:	261	Species:	Mus musculus

Alignment Length:	160	Identity:	44/160 - (27%)
Similarity:	74/160 - (46%)	Gaps:	26/160 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQ---DMINEVDADG---NGTIDFPE- 68
            ::|.|.:..||.||.|.:..|||..:::.|.|...:|.|:   :|.:.||..|   :|.|...|
Mouse    14 SQFFEIWLHFDADGSGYLEGKELQNLIQELLQARKKAGLELSPEMKSFVDQYGQRDDGKIGIVEL 78

  Fly    69 ---------FLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTD----- 119
                     ||.:.  :.:...|.||..:.:|.:|.|.:|||...||::.:.:|.||...
Mouse    79 AHVLPTEENFLLLF--RCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDT 141

  Fly   120 ---EEVDEMIREADIDGDGQVNYEEFVTMM 146
               |..|.|::..|.:.||::...|...::
Mouse   142 KLAEYTDLMLKLFDSNNDGKLELTEMARLL 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cam	NP_001246276.1	PTZ00184	1..149	CDD:185504	44/160 (28%)
Calb1	NP_033918.1	Interaction with RANBP9. /evidence=ECO:0000250\|UniProtKB:P05937	2..7
		EFh_HEF	16..259	CDD:329015	44/158 (28%)
		EF-hand motif	16..44	CDD:320075	10/27 (37%)
		EF-hand motif	57..86	CDD:320075	7/28 (25%)
		EF-hand motif	102..131	CDD:320075	9/28 (32%)
		EF-hand motif	146..175	CDD:320075	6/26 (23%)
		EF-hand motif	190..219	CDD:320075
		EF-hand motif	234..259	CDD:320075
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910